Pulmonary hydrogen and methane excretion following ingestion of an unabsorbable carbohydrate: A study of twins

G. Flatz, E. Czeizel, J. Métneki, S. D. Flatz, W. Kühnau, D. Jahn

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Pulmonary excretion of hydrogen and methane after administration of an unabsorbable disaccharide (lactulose) was determined in 228 adult Hungarian twins, 60 monozygous (MZ) and 54 dizygous (DZ) pairs. More than 98% of the subjects (224 of 228) excreted large amounts of hydrogen between 90 and 180 min after lactulose administration. Methane excretion in the fasting state was observed in 124 of 228 of the probands (54.4%), and 68 of 228 (29.8%) produced additional methane in response to lactulose ingestion. In contrast to hydrogen production, both methane excretion and production were significantly more frequent in females than in males. In the total group, and more distinctly in females, the correlation between peak hydrogen and methane concentrations was negative. Twin concordance of fasting methane excretion and lactuloseinduced methane production was near 70% in both MZ and DZ pairs. Heritability estimates of methane excretion and production based on intrapair correlation and variance were small ler than unity, and intrapair correlation coefficients were larger in twin pairs living apart than in those living in the same household. Methane excretion is comparatively frequent in the Hungarian population, and a substantial proportion of fasting methane excreters (55%) produce additional methane from lactulose. The sex difference of methane excretion appears to be characteristic of European populations. The twin data disprove regular Mendelian in-heritance of methane production and are suggestive of genetic effects in a multifactorial system.

Original languageEnglish
Pages (from-to)936-941
Number of pages6
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume4
Issue number6
Publication statusPublished - 1985

Fingerprint

Twin Studies
Methane
methane
hydrogen
Hydrogen
excretion
Eating
lungs
Carbohydrates
ingestion
carbohydrates
Lung
lactulose
Lactulose
fasting
Fasting
methane production
hydrogen production
disaccharides
Disaccharides

Keywords

  • Breath analysis
  • Hydrogen
  • Lactulose
  • Methane
  • Twin study

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health
  • Histology
  • Medicine (miscellaneous)
  • Food Science

Cite this

Pulmonary hydrogen and methane excretion following ingestion of an unabsorbable carbohydrate : A study of twins. / Flatz, G.; Czeizel, E.; Métneki, J.; Flatz, S. D.; Kühnau, W.; Jahn, D.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 4, No. 6, 1985, p. 936-941.

Research output: Contribution to journalArticle

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