Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells

Cláudia Valente, Maria José U. Ferreira, Pedro M. Abreu, Nora Gyémánt, Katalin Ugocsai, Judit Hohmann, Joseph Molnár

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo- 2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalPlanta Medica
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 1 2004

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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