Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells

Cláudia Valente, Maria José U Ferreira, Pedro M. Abreu, N. Gyémánt, Katalin Ugocsai, J. Hohmann, J. Molnár

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo- 2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalPlanta Medica
Volume70
Issue number1
DOIs
Publication statusPublished - Jan 2004

Fingerprint

Euphorbia
Jatropha
Polyesters
verapamil
Diterpenes
multiple drug resistance
polyesters
Multiple Drug Resistance
Verapamil
lymphoma
diterpenoids
Lymphoma
mice
cells
methodology
jatrophane
pubescene D
pubescene A
vitamin B 12 factor III

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells. / Valente, Cláudia; Ferreira, Maria José U; Abreu, Pedro M.; Gyémánt, N.; Ugocsai, Katalin; Hohmann, J.; Molnár, J.

In: Planta Medica, Vol. 70, No. 1, 01.2004, p. 81-84.

Research output: Contribution to journalArticle

Valente, Cláudia ; Ferreira, Maria José U ; Abreu, Pedro M. ; Gyémánt, N. ; Ugocsai, Katalin ; Hohmann, J. ; Molnár, J. / Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells. In: Planta Medica. 2004 ; Vol. 70, No. 1. pp. 81-84.
@article{a65e6f831e4a43689f3246e1f236ab94,
title = "Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells",
abstract = "The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo- 2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.",
author = "Cl{\'a}udia Valente and Ferreira, {Maria Jos{\'e} U} and Abreu, {Pedro M.} and N. Gy{\'e}m{\'a}nt and Katalin Ugocsai and J. Hohmann and J. Moln{\'a}r",
year = "2004",
month = "1",
doi = "10.1055/s-2004-815464",
language = "English",
volume = "70",
pages = "81--84",
journal = "Planta Medica",
issn = "0032-0943",
publisher = "Georg Thieme Verlag",
number = "1",

}

TY - JOUR

T1 - Pubescenes, Jatrophane Diterpenes, from Euphorbia pubescens, with Multidrug Resistance Reversing Activity on Mouse Lymphoma Cells

AU - Valente, Cláudia

AU - Ferreira, Maria José U

AU - Abreu, Pedro M.

AU - Gyémánt, N.

AU - Ugocsai, Katalin

AU - Hohmann, J.

AU - Molnár, J.

PY - 2004/1

Y1 - 2004/1

N2 - The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo- 2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.

AB - The macrocyclic jatrophane diterpene polyesters, pubescenes A-D (1-4) were isolated from the whole dried plant of Euphorbia pubescens, and evaluated for multidrug resistance (MDR) reversing activity on mouse lymphoma cells. All the compounds displayed very strong activity compared with the positive control verapamil. Pubescene D (4) is a new compound, whose structure was established as 3β,9α,-diacetoxy-7β-benzoyloxy-15β-hydroxy-14-oxo- 2βH-jatropha-5E,12E-diene by spectroscopic methods, including 1H-1H COSY, HMQC, HMBC and NOESY.

UR - http://www.scopus.com/inward/record.url?scp=1242320318&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1242320318&partnerID=8YFLogxK

U2 - 10.1055/s-2004-815464

DO - 10.1055/s-2004-815464

M3 - Article

C2 - 14765302

AN - SCOPUS:1242320318

VL - 70

SP - 81

EP - 84

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 1

ER -