Psychopharmacologic effects of some cholinesterase inhibitors in comparison with imipramine

Márton Fekete, Marianne Kürti

Research output: Contribution to journalArticle

Abstract

Imipramine and physostigmine, neostigmine and dyflos inhibited the catalepsy elicited by tetrabenazine, chlorpromazine and bulbocapnine respectively. This inhibition was demonstrable only at a given dose interval in certain cases. Both imipramine and cholinesterase inhibitors tested enhanced the hypermotility caused by amphetamine in mice, but not in conditioned rats. The effect exerted by chlorpromazine on conditioned reflex activity was inhibited by neostigmine and physostigmine. The results were discussed in relation to the effect produced by cholinesterase inhibitors on the permeability of the blood-brain barrier, and in relation to the possible significance of the cholinergic affinity of imipramine on its pharmacological effects.

Original languageEnglish
Pages (from-to)238-248
Number of pages11
JournalPsychopharmacologia
Volume18
Issue number3
DOIs
Publication statusPublished - Sep 1 1970

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Keywords

  • Amphetamine
  • Catalepsy
  • Cholinesterase Inhibitors
  • Imipramine

ASJC Scopus subject areas

  • Pharmacology

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