Imipramine and physostigmine, neostigmine and dyflos inhibited the catalepsy elicited by tetrabenazine, chlorpromazine and bulbocapnine respectively. This inhibition was demonstrable only at a given dose interval in certain cases. Both imipramine and cholinesterase inhibitors tested enhanced the hypermotility caused by amphetamine in mice, but not in conditioned rats. The effect exerted by chlorpromazine on conditioned reflex activity was inhibited by neostigmine and physostigmine. The results were discussed in relation to the effect produced by cholinesterase inhibitors on the permeability of the blood-brain barrier, and in relation to the possible significance of the cholinergic affinity of imipramine on its pharmacological effects.
- Cholinesterase Inhibitors
ASJC Scopus subject areas