PSYCHE CPMG-HSQMBC: An NMR Spectroscopic Method for Precise and Simple Measurement of Long-Range Heteronuclear Coupling Constants

István Timári, Lászlõ Szilágyi, Katalin E. Kövér

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Among the NMR spectroscopic parameters, long-range heteronuclear coupling constants convey invaluable information on torsion angles relevant to glycosidic linkages of carbohydrates. A broadband homonuclear decoupled PSYCHE CPMG-HSQMBC method for the precise and direct measurement of multiple-bond heteronuclear couplings is presented. The PSYCHE scheme built into the pulse sequence efficiently eliminates unwanted proton-proton splittings from the heteronuclear multiplets so that the desired heteronuclear couplings can be determined simply by measuring frequency differences between peak maxima of pure antiphase doublets. Moreover, PSYCHE CPMG-HSQMBC can provide significant improvement in sensitivity as compared to an earlier Zangger-Sterk-based method. Applications of the proposed pulse sequence are demonstrated for the extraction of nJ(1H,77Se) and nJ(1H,13C) values, respectively, in carbohydrates; further extensions can be envisioned in any J-based structural and conformational studies.

Original languageEnglish
Pages (from-to)13939-13942
Number of pages4
JournalChemistry - A European Journal
Volume21
Issue number40
DOIs
Publication statusPublished - Sep 1 2015

Keywords

  • HSQMBC
  • NMR spectroscopy
  • broadband homonuclear decoupling
  • carbohydrates
  • long-range heteronuclear coupling

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

Fingerprint Dive into the research topics of 'PSYCHE CPMG-HSQMBC: An NMR Spectroscopic Method for Precise and Simple Measurement of Long-Range Heteronuclear Coupling Constants'. Together they form a unique fingerprint.

  • Cite this