PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons

L. Vutskits, Z. Djebbara-Hannas, H. Zhang, J. P. Paccaud, P. Durbec, G. Rougon, D. Muller, J. Z. Kiss

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

We show that the loss or inactivation of the polysialic acid (PSA) tail of neural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. The mechanism by which this negative effect is mediated appears to involve the neuronal response to brain-derived neurotrophic factor (BDNF): (i) in the absence of PSA or in the presence of excess free PSA added to the culture medium, BDNF-induced cell signalling is reduced; (ii) the addition of exogenous BDNF to the medium reverses the effect of PSA loss or inactivation. These data suggest that PSA-NCAM, previously shown to modulate cell migration and plasticity, is needed for an adequate sensitivity of neurons to BDNF.

Original languageEnglish
Pages (from-to)1391-1402
Number of pages12
JournalEuropean Journal of Neuroscience
Volume13
Issue number7
DOIs
Publication statusPublished - May 1 2001

Keywords

  • BDNF
  • Neuronal survival
  • PSA-NCAM
  • Rat
  • TrkB

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons'. Together they form a unique fingerprint.

  • Cite this

    Vutskits, L., Djebbara-Hannas, Z., Zhang, H., Paccaud, J. P., Durbec, P., Rougon, G., Muller, D., & Kiss, J. Z. (2001). PSA-NCAM modulates BDNF-dependent survival and differentiation of cortical neurons. European Journal of Neuroscience, 13(7), 1391-1402. https://doi.org/10.1046/j.0953-816X.2001.01516.x