Proteus virulence: Involvement of the pore forming α-hemolysin

V. Tóth, L. Emődy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The genus Proteus belongs to the tribe of Proteae in the family of Enterobacteriaceae, and consists of five species: P. mirabilis, P. vulgaris, P. morganii, P. penneri and P. myxofaciens. They are distinguished from the rest of Enterobacteriaceae by their ability to deaminate phenylalanine and tryptophane. They hydrolyze urea and gelatin and fail to ferment lactose, mannose, dulcitol and malonate; and do not form lysine and arginine decarboxylase or β-galactosidase [1]. Colonies produce distinct "burned chocolate" odor and frequently show the characteristics of swarming motility on solid media. P. mirabilis, P. vulgaris and P. morganii are widely recognized human pathogens. They have been isolated from urinary tract infections, wounds, ear, and nosocomial bacteremic infections, often in immuncompromised patients [2-6]. P. myxofaciens has no clinical interest to this time. P. penneri as species nova was nominated by the recommendation of Hickman and co-workers [7]. Formerly it was recognized as P. vulgaris biogroup 1 or indole negative P. vulgaris [8, 9]. Although it has been less commonly isolated from clinical samples than the other three human pathogenic Proteus species, it has nevertheless been connected with infections of the urinary tract, wounds and has been isolated from the feces of both healthy and diarrheic individuals [10-12]. Potential virulence factors responsible for virulence of Proteae are: IgA protease, urease, type3 fimbriae associated with MR/K haemagglutinins of at least two antigenic types, endotoxin, swarming motility and HlyA and/or HpmA type hemolysins [for review see ref. 13]. In the followings we give a survey of accumulated concepts about the position and characteristics of HlyA type α-hemolysins both in general and with emphasis on virulence functions in the tribe of Proteae.

Original languageEnglish
Pages (from-to)457-470
Number of pages14
JournalActa Microbiologica et Immunologica Hungarica
Volume47
Issue number4
Publication statusPublished - 2000

Fingerprint

Mirabilis
Proteus
IgA-specific serine endopeptidase
Hemolysin Proteins
lysine decarboxylase
Enterobacteriaceae
Population Groups
Urinary Tract Infections
Virulence
Galactitol
Galactosidases
Urease
Wounds and Injuries
Hemagglutinins
Virulence Factors
Gelatin
Lactose
Mannose
Cross Infection
Phenylalanine

Keywords

  • α-hemolysin
  • Proteus virulence

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Medicine(all)
  • Microbiology

Cite this

Proteus virulence : Involvement of the pore forming α-hemolysin. / Tóth, V.; Emődy, L.

In: Acta Microbiologica et Immunologica Hungarica, Vol. 47, No. 4, 2000, p. 457-470.

Research output: Contribution to journalArticle

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