A fehérjekutatás a klinikai enzimológiai gyakorlatban: a kreatinkináz és alkalikus foszfatáz enzimek polimorfizmusa.

Translated title of the contribution: Proteomics in clinical enzymology: polymorphism of creatine kinase and alkaline phosphatase

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: The clinical proteomics is dedicated to the use of the proteomics in the clinical laboratory science. AIMS: Examples for the importance of clinical proteomics are provided by studies on the polymorphisms of creatine kinase and alkaline phosphatase enzymes. METHODS: The different (immunoinhibition, electrophoretic, immunochemistry) assays for determination of a cardiac marker (creatine kinase 2) are compared in hospital patients. Isoform analysis of alkaline phosphatase is performed in benign, transient hyperphosphatasemia. RESULTS: The author reviews recent knowledge on polymorphism of creatine kinase (isoenzymes, isoforms, macro types), and alkaline phosphatase (isoenzymes, their cancer related variants, isoforms). The origin of falsely high cardiac marker (creatine kinase 2) determined by the immunoinhibition assay could be related to the presence of macro creatine kinase (both types), creatine kinase isoenzyme 1, and their mixtures. After reviewing the recent findings on the syndrome of benign, transient hyperphosphatasemia, a case of a 1-year-old Hungarian boy with this syndrome is presented. CONCLUSIONS: The author points out that the appropriate use of clinical proteomics (the polymorphisms of creatine kinase and alkaline phosphatase enzymes) may improve the diagnostic efficiency of the clinical laboratory tests.

Original languageHungarian
Pages (from-to)1021-1025
Number of pages5
JournalOrvosi Hetilap
Volume143
Issue number19
Publication statusPublished - May 12 2002

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Creatine Kinase
Proteomics
Alkaline Phosphatase
Isoenzymes
Protein Isoforms
Medical Laboratory Science
Immunochemistry
Enzymes
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

A fehérjekutatás a klinikai enzimológiai gyakorlatban : a kreatinkináz és alkalikus foszfatáz enzimek polimorfizmusa. / Góth, L.

In: Orvosi Hetilap, Vol. 143, No. 19, 12.05.2002, p. 1021-1025.

Research output: Contribution to journalArticle

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abstract = "INTRODUCTION: The clinical proteomics is dedicated to the use of the proteomics in the clinical laboratory science. AIMS: Examples for the importance of clinical proteomics are provided by studies on the polymorphisms of creatine kinase and alkaline phosphatase enzymes. METHODS: The different (immunoinhibition, electrophoretic, immunochemistry) assays for determination of a cardiac marker (creatine kinase 2) are compared in hospital patients. Isoform analysis of alkaline phosphatase is performed in benign, transient hyperphosphatasemia. RESULTS: The author reviews recent knowledge on polymorphism of creatine kinase (isoenzymes, isoforms, macro types), and alkaline phosphatase (isoenzymes, their cancer related variants, isoforms). The origin of falsely high cardiac marker (creatine kinase 2) determined by the immunoinhibition assay could be related to the presence of macro creatine kinase (both types), creatine kinase isoenzyme 1, and their mixtures. After reviewing the recent findings on the syndrome of benign, transient hyperphosphatasemia, a case of a 1-year-old Hungarian boy with this syndrome is presented. CONCLUSIONS: The author points out that the appropriate use of clinical proteomics (the polymorphisms of creatine kinase and alkaline phosphatase enzymes) may improve the diagnostic efficiency of the clinical laboratory tests.",
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