Proteolytic enzymes in otosclerosis

O. Ribari, I. Sziklai, G. J. Kiss

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The otosclerotic stapes footplate exhibits higher activities of cathepsin D and H and collagenase-like peptidase than those of normal cortical bone. The elevated enzyme activities of osteoblastic origin (C1-peptidase and cathepsin D) emphasize the essential and probably primary role of the bone-forming cells, not only in bone formation, but in resorption as well. The highest activity of cathepsin D from among the measured enzymes highlights the adjuvant role of acidic glucosaminoglycans in the otosclerotic demineralization process. As the osteoblastic osteoid synthesis is known to be sharply reduced in otosclerotic bone remodelling, and the above data emphasize the role of proteolytic enzymes of osteoblastic origin too, indirectly, osteoblasts seem to be the otosclerosis signal-transducing cells.

Original languageEnglish
Pages (from-to)282-286
Number of pages5
JournalORL
Volume49
Issue number6
Publication statusPublished - 1987

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Otosclerosis
Cathepsin D
Peptide Hydrolases
proline dipeptidase
Microbial Collagenase
Cathepsin H
Stapes
Bone Remodeling
Enzymes
Osteoblasts
Osteogenesis
Bone and Bones

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Ribari, O., Sziklai, I., & Kiss, G. J. (1987). Proteolytic enzymes in otosclerosis. ORL, 49(6), 282-286.

Proteolytic enzymes in otosclerosis. / Ribari, O.; Sziklai, I.; Kiss, G. J.

In: ORL, Vol. 49, No. 6, 1987, p. 282-286.

Research output: Contribution to journalArticle

Ribari, O, Sziklai, I & Kiss, GJ 1987, 'Proteolytic enzymes in otosclerosis', ORL, vol. 49, no. 6, pp. 282-286.
Ribari O, Sziklai I, Kiss GJ. Proteolytic enzymes in otosclerosis. ORL. 1987;49(6):282-286.
Ribari, O. ; Sziklai, I. ; Kiss, G. J. / Proteolytic enzymes in otosclerosis. In: ORL. 1987 ; Vol. 49, No. 6. pp. 282-286.
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