Proteoglycans in liver cancer

Kornélia Baghy, P. Tátrai, Eszter Regös, I. Kovalszky

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Proteoglycans are a group of molecules that contain at least one glycosaminoglycan chain, such as a heparan, dermatan, chondroitin, or keratan sulfate, covalently attached to the protein core. These molecules are categorized based on their structure, localization, and function, and can be found in the extracellular matrix, on the cell surface, and in the cytoplasm. Cell-surface heparan sulfate proteoglycans, such as syndecans, are the primary type present in healthy liver tissue. However, deterioration of the liver results in overproduction of other proteoglycan types. The purpose of this article is to provide a current summary of the most relevant data implicating proteoglycans in the development and progression of human and experimental liver cancer. A review of our work and other studies in the literature indicate that deterioration of liver function is accompanied by an increase in the amount of chondroitin sulfate proteoglycans. The alteration of proteoglycan composition interferes with the physiologic function of the liver on several levels. This article details and discusses the roles of syndecan-1, glypicans, agrin, perlecan, collagen XVIII/ endostatin, endocan, serglycin, decorin, biglycan, asporin, fibromodulin, lumican, and versican in liver function. Specifically, glypicans, agrin, and versican play significant roles in the development of liver cancer. Conversely, the presence of decorin could potentially provide protective effects.

Original languageEnglish
Pages (from-to)379-393
Number of pages15
JournalWorld Journal of Gastroenterology
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 7 2016

Fingerprint

Proteoglycans
Liver Neoplasms
Agrin
Glypicans
Versicans
Liver
Decorin
Collagen Type XVIII
Syndecans
Syndecan-1
Biglycan
Endostatins
Keratan Sulfate
Chondroitin Sulfate Proteoglycans
Dermatan Sulfate
Heparan Sulfate Proteoglycans
Chondroitin Sulfates
Human Development
Glycosaminoglycans
Extracellular Matrix

Keywords

  • Cancer
  • Cell regulation
  • Heparan sulfate
  • Liver
  • Proteoglycans

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Proteoglycans in liver cancer. / Baghy, Kornélia; Tátrai, P.; Regös, Eszter; Kovalszky, I.

In: World Journal of Gastroenterology, Vol. 22, No. 1, 07.01.2016, p. 379-393.

Research output: Contribution to journalArticle

Baghy, Kornélia ; Tátrai, P. ; Regös, Eszter ; Kovalszky, I. / Proteoglycans in liver cancer. In: World Journal of Gastroenterology. 2016 ; Vol. 22, No. 1. pp. 379-393.
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