Proteins, RNAs and chaperones in enzyme evolution: A folding perspective

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The present roles of RNA molecules as templates and of proteins as cellular catalysts may not have always been so clearly defined during evolution. Recent work on ribozymes shows that the catalytic activity of early RNAs may have been more general than previously thoght. How did evolution select proteins, not RNA, to be the major biological catalysts? Why were chaperones necessary for the evolution of modern protein enzymes?.

Original languageEnglish
Pages (from-to)147-149
Number of pages3
JournalTrends in Biochemical Sciences
Issue number5
Publication statusPublished - May 1997


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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