Proteins and peptides for the immunodiagnosis and therapy of Mycobacterium tuberculosis infections

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Tuberculosis, caused by Mycobacterium tuberculosis, is one of the world's deadliest communicable diseases and present in all regions of the world. The Global Tuberculosis Report 2014 shows higher global totals for new cases and deaths in 2013 than previously, an estimated 9.0million people developed and 1.5million died from the disease. The disease affects both BCG-vaccinated and non-vaccinated people. A third of the world population is believed to be latently infected. Latent tuberculosis (LTBI) is an asymptomatic phase, but bacilli have the potential to reactivate the disease. The risk of developing active tuberculosis is around 10% in the case of LTBI, but this percentage can be higher among individuals with decreased host immunity, (e.g. newborns, seniors, HIV-positive or AIDS patients, people with diabetes, cancer patients, organ transplant recipients and people undergoing treatment for autoimmune diseases). Protein and/or peptide based immunodiagnosis and immunotherapy (vaccine) of tuberculosis require better understanding of the processes involved in the induction of the immune responses during bacterial infection as well as during the progression of the disease at cellular, and even at molecular level. There is a need to genome/proteome wide analysis and identification of proteins involved in specific immune recognition processes. The following chapter is aiming to outline recent progress in searching for relevant proteins including immunodominant T and B cell epitope regions of M. tuberculosis. We wish also to demonstrate that this complex task could only be achieved by applying novel, combined approaches (bioinformatics, theoretical and experimental) and strategies. Together with the brief references to early attempts, special focus was taken to survey findings related to the translation of these discoveries into the development of protein (e.g. fusion proteins) or synthetic peptide epitope constructs to be utilized in early, sensitive and specific diagnosis and/or efficient targeted therapy including vaccination in tuberculosis.

Original languageEnglish
Title of host publicationAmino Acids, Peptides and Proteins, Volume 40
PublisherRoyal Society of Chemistry
Pages146-198
Number of pages53
Volume40
ISBN (Print)9781782620594
DOIs
Publication statusPublished - 2016

Publication series

NameAmino Acids, Peptides and Proteins
Volume40
ISSN (Print)13615904

ASJC Scopus subject areas

  • Biochemistry

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  • Cite this

    Bősze, S., & Hudecz, F. (2016). Proteins and peptides for the immunodiagnosis and therapy of Mycobacterium tuberculosis infections. In Amino Acids, Peptides and Proteins, Volume 40 (Vol. 40, pp. 146-198). (Amino Acids, Peptides and Proteins; Vol. 40). Royal Society of Chemistry. https://doi.org/10.1039/9781782622680-00146