Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects

Bernadett Farago, G. Talián, K. Komlósi, Gergely Nagy, T. Berki, Agnes Gyetvai, Z. Szekanecz, Zoltan Nyarady, C. Kiss, P. Németh, L. Czirják, B. Melegh

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The C1858T allele of the PTPN22 gene has been reported to confer risk for RA; but in some reports, the effect was restricted to RF- and/or anti-CCP-seropositive patients. Hungarian RA patients and matched controls were genotyped. The 1858T allele showed an increased prevalence in RA patients compared to controls. The 1858T allele represents a risk factor in the whole RA population (P = 0.001); an association was found both in RF-seropositive (P = 0.001) and anti-CCP-seropositive patients (P = 0.001), and in subjects with the combination of these factors (P = 0.002). In TT homozygotes, the estimated susceptibility to RA was more than double (OR = 5.04) of that seen in TC heterozygotes (OR = 1.89); the same gene dosage effect was observed in all seropositive RA subgroups. Our data show that the Hungarian RA patients belong to the populations in which the 1858T allele represents a susceptibility factor both in the RF- and/or anti-CCP-seropositive subjects, and the association exhibit a gene dosage dependency.

Original languageEnglish
Pages (from-to)793-796
Number of pages4
JournalRheumatology International
Volume29
Issue number7
DOIs
Publication statusPublished - May 2009

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Protein Tyrosine Phosphatases
Rheumatoid Arthritis
Alleles
Gene Dosage
Genes
Homozygote
Heterozygote
Population

Keywords

  • Anti-CCP
  • Polymorphism
  • PTPN22
  • RF
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects. / Farago, Bernadett; Talián, G.; Komlósi, K.; Nagy, Gergely; Berki, T.; Gyetvai, Agnes; Szekanecz, Z.; Nyarady, Zoltan; Kiss, C.; Németh, P.; Czirják, L.; Melegh, B.

In: Rheumatology International, Vol. 29, No. 7, 05.2009, p. 793-796.

Research output: Contribution to journalArticle

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AU - Gyetvai, Agnes

AU - Szekanecz, Z.

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