Protein status in pacreatis-Transthyretin is a sensitive biomarker of malnutrition in acute and chronic pancreatitis

Natalia Lasztity, L. Bíró, Eva Nemeth, A. Pap, M. Antal

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Malnutrition may develop in acute pancreatitis (AP), accompanied by hypermetabolism and high nutritional requirements, and in chronic pancreatitis (CP). We measured the incidence of protein malnutrition in AP and CP by comparing different serum biomarkers of protein metabolism and inflammation. Thirty-five patients with acute (27 moderate, 8 severe), and 35 with chronic, pancreatitis were enrolled in the study. Serum transthyretin, albumin, transferrin and C-reactive protein (CRP) concentrations were measured in AP at admission, after 1 and 2 weeks of jejunal feeding, and in patients with CP at follow-up. In AP, at admission the transthyretin level was low in 74%, transferrin in 48%, and albumin in 29% of patients. In severe pancreatitis, transthyretin levels were significantly lower than in moderate forms (7.5±2.43 vs. 14.39±6.8 mg/dl, p

Original languageEnglish
Pages (from-to)1320-1324
Number of pages5
JournalClinical Chemistry and Laboratory Medicine
Volume40
Issue number12
DOIs
Publication statusPublished - 2002

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Prealbumin
Chronic Pancreatitis
Biomarkers
Malnutrition
Pancreatitis
Transferrin
Albumins
Proteins
Metabolism
C-Reactive Protein
Nutritional Requirements
Serum Albumin
Blood Proteins
Inflammation
Incidence

Keywords

  • C-reactive protein
  • Jejunal feeding
  • Pancreatis
  • Protein malnutrition
  • Transthyretin

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Protein status in pacreatis-Transthyretin is a sensitive biomarker of malnutrition in acute and chronic pancreatitis. / Lasztity, Natalia; Bíró, L.; Nemeth, Eva; Pap, A.; Antal, M.

In: Clinical Chemistry and Laboratory Medicine, Vol. 40, No. 12, 2002, p. 1320-1324.

Research output: Contribution to journalArticle

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AU - Pap, A.

AU - Antal, M.

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