Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning

Zoltán Asztalos, Jörg Von Wegerer, Gerald Wustmann, V. Dombrádi, János Gausz, Hanns Christof Spatz, P. Friedrich

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The learning and memory of Drosophila melanogaster strains carrying the Su-var(3)601 mutation, which is known to affect the structural gene of a protein phosphatase 1 isoenzyme, PP1(87B), were studied in various behavioral paradigms. Three lines of Drosophila comprising the Su-var(3)601 mutation in different genetic backgrounds were shown to have diminished protein phosphatase 1 activity and behavioral anomalies. Associative olfactory learning and visual conditioning were impaired. Olfactory acuity for the odorants used and response to electric shock were largely unchanged in the mutant lines. The motility and flight activity of the mutants were reduced. Habituation of the landing response, a nonassociative learning process, was more pronounced in heterozygotes of the mutants than in the wild-type control strains. Taken together with earlier data, the results indicate that protein phosphatase PP1(87B), while affecting several cellular processes, is also part of the biochemical machinery of various forms of neuromodulation in Drosophila.

Original languageEnglish
Pages (from-to)924-930
Number of pages7
JournalJournal of Neuroscience
Volume13
Issue number3
Publication statusPublished - 1993

Fingerprint

Protein Phosphatase 1
Drosophila
Learning
Mutation
Phosphoprotein Phosphatases
Heterozygote
Drosophila melanogaster
Isoenzymes
Shock
Proteins

Keywords

  • Associative learning
  • Drosophila
  • Habituation
  • Landing response
  • Memory
  • Phosphatase-deficient mutant
  • Protein phosphatase 1

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning. / Asztalos, Zoltán; Von Wegerer, Jörg; Wustmann, Gerald; Dombrádi, V.; Gausz, János; Spatz, Hanns Christof; Friedrich, P.

In: Journal of Neuroscience, Vol. 13, No. 3, 1993, p. 924-930.

Research output: Contribution to journalArticle

Asztalos, Z, Von Wegerer, J, Wustmann, G, Dombrádi, V, Gausz, J, Spatz, HC & Friedrich, P 1993, 'Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning', Journal of Neuroscience, vol. 13, no. 3, pp. 924-930.
Asztalos, Zoltán ; Von Wegerer, Jörg ; Wustmann, Gerald ; Dombrádi, V. ; Gausz, János ; Spatz, Hanns Christof ; Friedrich, P. / Protein phosphatase 1-deficient mutant Drosophila is affected in habituation and associative learning. In: Journal of Neuroscience. 1993 ; Vol. 13, No. 3. pp. 924-930.
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