Protein oxidation during aging of the nematode Caenorhabditis elegans

Naoaki Ishii, Sataro Goto, Philip S. Hartman

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The nematode Caenorhabditis elegans has proven a robust genetic model for studies of aging, including the roles of oxidative stress and protein damage. In this review, we focus on the genetics of select long-lived (e.g., age-1, daf-2, daf-16) and short-lived (e.g., mev-1) mutants that have proven useful in revealing the relationships that exist among oxidative stress, life span, and protein oxidation. The former are known to control an insulin/IGF-1-like pathway in C. elegans, while the latter affect mitochondrial function.

Original languageEnglish
Pages (from-to)1021-1025
Number of pages5
JournalFree Radical Biology and Medicine
Volume33
Issue number8
DOIs
Publication statusPublished - Oct 15 2002

Keywords

  • Aging
  • C. elegans
  • Energy metabolism
  • Free radicals
  • Protein oxidation
  • age-1
  • daf-2
  • mev-1

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)

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