Protein Misfolding, Mitochondrial Disturbances, And Kynurenines In The Pathogenesis Of Neurodegenerative Disorders

Gabriella Gárdián, K. Sas, J. Toldi, L. Vécsei

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As a population ages, neurodegenerative diseases become increasingly prevalent. These are different clinical entities, though they display many common features in their clinical, biochemical, and morphological appearance. The majority of them have both genetic and environmental components in their pathomechanism. The genetic background involves a single gene mutation (for example, spinocerebellar ataxias 1, 2, and 3 and Huntington's disease [PD]), heterozygote gene modifications following the patterns of the Mendelian laws (familial Parkinson's disease [PD] and familial Alzheimer's disease [AD]), multiple predisposing genes (sporadic PD and sporadic AD), or mitochondrial DNA defects. Protein misfolding, mitochondrial impairment, oxidative stress, endoplasmic reticulum stress, excitotoxicity, caspase cascade activation, and apoptosis are common mechanisms acknowledged to lead to cell death in the different neurodegenerative disorders.

Original languageEnglish
Title of host publicationNeurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging
PublisherOxford University Press
ISBN (Print)9780199864874, 9780195326697
DOIs
Publication statusPublished - Jan 1 2010

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Kynurenine
Mitochondrial Proteins
Neurodegenerative Diseases
Spinocerebellar Ataxias
Parkinson Disease
Alzheimer Disease
Machado-Joseph Disease
Genes
Endoplasmic Reticulum Stress
Huntington Disease
Heterozygote
Caspases
Mitochondrial DNA
Oxidative Stress
Cell Death
Apoptosis
Mutation
Population

Keywords

  • Apoptosis
  • Endoplasmic reticulum stress
  • Excitotoxicity
  • Neurodegenerative disorders
  • Oxidative stress
  • Protein misfolding

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Protein Misfolding, Mitochondrial Disturbances, And Kynurenines In The Pathogenesis Of Neurodegenerative Disorders. / Gárdián, Gabriella; Sas, K.; Toldi, J.; Vécsei, L.

Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging. Oxford University Press, 2010.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gárdián, Gabriella ; Sas, K. ; Toldi, J. ; Vécsei, L. / Protein Misfolding, Mitochondrial Disturbances, And Kynurenines In The Pathogenesis Of Neurodegenerative Disorders. Neurovascular Medicine: Pursuing Cellular Longevity for Healthy Aging. Oxford University Press, 2010.
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