Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation

Norbert Bencsik, Zsófia Szíber, Hanna Liliom, Krisztián Tárnok, Sándor Borbély, Márton Gulyás, Anikó Rátkai, Attila Szucs, Diána Hazai-Novák, Kornelia Ellwanger, Bence Rácz, Klaus Pfizenmaier, Angelika Hausser, Katalin Schlett

Research output: Contribution to journalArticle

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Abstract

Actin turnover in dendritic spines influences spine development, morphology, and plasticity, with functional consequences on learning and memory formation. In nonneuronal cells, protein kinase D (PKD) has an important role in stabilizing F-actin via multiple molecular pathways. Using in vitro models of neuronal plasticity, such as glycine-induced chemical long-term potentiation (LTP), known to evoke synaptic plasticity, or long-term depolarization block by KCl, leading to homeostatic morphological changes, we show that actin stabilization needed for the enlargement of dendritic spines is dependent on PKD activity. Consequently, impaired PKD functions attenuate activity-dependent changes in hippocampal dendritic spines, including LTP formation, cause morphological alterations in vivo, and have deleterious consequences on spatial memory formation. We thus provide compelling evidence that PKD controls synaptic plasticity and learning by regulating actin stability in dendritic spines.

Original languageEnglish
Pages (from-to)771-783
Number of pages13
JournalJournal of Cell Biology
Volume210
Issue number5
DOIs
Publication statusPublished - Aug 31 2015

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Dendritic Spines
Neuronal Plasticity
Actins
Long-Term Potentiation
Learning
Glycine
Spine
protein kinase D

ASJC Scopus subject areas

  • Cell Biology

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Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation. / Bencsik, Norbert; Szíber, Zsófia; Liliom, Hanna; Tárnok, Krisztián; Borbély, Sándor; Gulyás, Márton; Rátkai, Anikó; Szucs, Attila; Hazai-Novák, Diána; Ellwanger, Kornelia; Rácz, Bence; Pfizenmaier, Klaus; Hausser, Angelika; Schlett, Katalin.

In: Journal of Cell Biology, Vol. 210, No. 5, 31.08.2015, p. 771-783.

Research output: Contribution to journalArticle

Bencsik, N, Szíber, Z, Liliom, H, Tárnok, K, Borbély, S, Gulyás, M, Rátkai, A, Szucs, A, Hazai-Novák, D, Ellwanger, K, Rácz, B, Pfizenmaier, K, Hausser, A & Schlett, K 2015, 'Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation', Journal of Cell Biology, vol. 210, no. 5, pp. 771-783. https://doi.org/10.1083/jcb.201501114
Bencsik, Norbert ; Szíber, Zsófia ; Liliom, Hanna ; Tárnok, Krisztián ; Borbély, Sándor ; Gulyás, Márton ; Rátkai, Anikó ; Szucs, Attila ; Hazai-Novák, Diána ; Ellwanger, Kornelia ; Rácz, Bence ; Pfizenmaier, Klaus ; Hausser, Angelika ; Schlett, Katalin. / Protein kinase D promotes plasticity-induced F-actin stabilization in dendritic spines and regulates memory formation. In: Journal of Cell Biology. 2015 ; Vol. 210, No. 5. pp. 771-783.
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