Protein kinase D: An intracellular traffic regulator on the move

Johan Van Lint, An Rykx, Yusuke Maeda, Tibor Vantus, Sabine Sturany, Vivek Malhotra, Jackie R. Vandenheede, Thomas Seufferlein

Research output: Contribution to journalReview article

195 Citations (Scopus)

Abstract

Recent research has identified protein kinase D (PKD, also called PKCmu) as a serine/threonine kinase with potentially important roles in growth factor signaling as well as in stress-induced signaling. Moreover, PKD has emerged as an important regulator of plasma membrane enzymes and receptors, in some cases mediating cross-talk between different signaling systems. The recent discovery of two additional kinases belonging to the PKD family and the plethora of proteins that interact with PKD point to a multifaceted regulation and a multifunctional role for these enzymes, with functions in processes as diverse as cell proliferation, apoptosis, immune cell regulation, tumor cell invasion and regulation of Golgi vesicle fission.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalTrends in Cell Biology
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1 2002

ASJC Scopus subject areas

  • Cell Biology

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  • Cite this

    Van Lint, J., Rykx, A., Maeda, Y., Vantus, T., Sturany, S., Malhotra, V., Vandenheede, J. R., & Seufferlein, T. (2002). Protein kinase D: An intracellular traffic regulator on the move. Trends in Cell Biology, 12(4), 193-200. https://doi.org/10.1016/S0962-8924(02)02262-6