Protein kinase D: A family affair

An Rykx, Line De Kimpe, Svetlana Mikhalap, Tibor Vantus, Thomas Seufferlein, Jackie R. Vandenheede, Johan Van Lint

Research output: Contribution to journalShort survey

181 Citations (Scopus)

Abstract

The protein kinase D family of enzymes consists of three isoforms: PKD1/PKCμ, PKD2 and PKD3/PKCν. They all share a similar architecture with regulatory sub-domains that play specific roles in the activation, translocation and function of the enzymes. The PKD enzymes have recently been implicated in very diverse cellular functions, including Golgi organization and plasma membrane directed transport, metastasis, immune responses, apoptosis and cell proliferation.

Original languageEnglish
Pages (from-to)81-86
Number of pages6
JournalFEBS letters
Volume546
Issue number1
DOIs
Publication statusPublished - Jul 3 2003

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Keywords

  • Apoptosis
  • Cell proliferation
  • Golgi apparatus
  • Protein kinase Cμ
  • Protein kinase D
  • Signal transduction
  • Stress signaling
  • Tumor cell invasion

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Rykx, A., De Kimpe, L., Mikhalap, S., Vantus, T., Seufferlein, T., Vandenheede, J. R., & Van Lint, J. (2003). Protein kinase D: A family affair. FEBS letters, 546(1), 81-86. https://doi.org/10.1016/S0014-5793(03)00487-3