Protein Kinase C isoforms -Implications to thrombosis

Ramya Turaga, Yamini S. Bynagari, B. Nagy, Satya P. Kunapuli

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Protein Kinase C isoforms (PKCs) are serine/threonine kinases that mediate multiple cellular functions and have been implicated in the patho-physiology of cancer, diabetes and cardiovascular diseases such as ischemia, cardiac hypertrophy, heart failure, and atherosclerosis. Blood components such as platelets contribute to thrombus formation resulting in stroke and myocardial infarction under patho-physiological conditions. PKCs mediate distinct platelet functional responses upon stimulation of different platelet receptors. Current research strategies employ the usage of PKC isoform-specific inhibitors to dissect their role in mediating platelet functional responses. This strategy has been complemented with studies in murine platelets lacking a specific PKC isoform. Furthermore, these studies have been extended to in vivo thrombosis animal models in order to correlate the in vitro observations to the formation of thrombus in vivo. It has been shown that PKCs play an important role in platelet secretion, aggregation and thrombus stabilization. In the current review, we discuss the role of various classes of PKCs in the complexity of signaling interplay in platelets, their implications to thrombosis, and also outline the possible therapeutic interventions.

Original languageEnglish
Pages (from-to)353-362
Number of pages10
JournalCurrent Signal Transduction Therapy
Volume6
Issue number3
DOIs
Publication statusPublished - Sep 2011

Fingerprint

Protein Kinase C
Protein Isoforms
Thrombosis
Blood Platelets
Cardiomegaly
Platelet Aggregation
Atherosclerosis
Cardiovascular Diseases
Ischemia
Animal Models
Heart Failure
Stroke
Myocardial Infarction
Research
Neoplasms

Keywords

  • Platelets
  • Protein Kinase C
  • Signaling
  • Thrombosis

ASJC Scopus subject areas

  • Endocrinology
  • Pharmacology (medical)

Cite this

Protein Kinase C isoforms -Implications to thrombosis. / Turaga, Ramya; Bynagari, Yamini S.; Nagy, B.; Kunapuli, Satya P.

In: Current Signal Transduction Therapy, Vol. 6, No. 3, 09.2011, p. 353-362.

Research output: Contribution to journalArticle

Turaga, Ramya ; Bynagari, Yamini S. ; Nagy, B. ; Kunapuli, Satya P. / Protein Kinase C isoforms -Implications to thrombosis. In: Current Signal Transduction Therapy. 2011 ; Vol. 6, No. 3. pp. 353-362.
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