Protein kinase C inhibitor BIM suspended TRPV1 effect on mu-opioid receptor

Mária Wollemann, Fanni Tóth, S. Benyhe

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of the present study was to elucidate the role of protein kinase A and C in the mechanism of capsaicin inhibition on mu-opiate receptors. H89, a protein kinase A inhibitor and BIM (bisindolylmaleimide), a protein kinase C inhibitor were used for this purpose. BIM suspended the inhibition of capsaicin in endomorphin-1 competition binding. The addition of BIM alone had no effect itself on this reaction. H89 however, exerted a strong inhibitory effect on the endomorphin-1 binding. We can conclude that protein kinase C certainly plays a role in the inhibition of capsaicin. The role of protein kinase A in this reaction could not be established, owing to the blocking effect of H89 on the mu-opioid receptors.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalBrain Research Bulletin
Volume90
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

Protein C Inhibitor
mu Opioid Receptor
Capsaicin
Protein Kinase Inhibitors
Cyclic AMP-Dependent Protein Kinases
Protein Kinase C
Opioid Receptors
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
bisindolylmaleimide
endomorphin 1

Keywords

  • BIM
  • Capsaicin
  • Endomorphin-1
  • H89
  • Protein kinase A
  • Protein kinase C

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Protein kinase C inhibitor BIM suspended TRPV1 effect on mu-opioid receptor. / Wollemann, Mária; Tóth, Fanni; Benyhe, S.

In: Brain Research Bulletin, Vol. 90, No. 1, 01.2013, p. 114-117.

Research output: Contribution to journalArticle

Wollemann, Mária ; Tóth, Fanni ; Benyhe, S. / Protein kinase C inhibitor BIM suspended TRPV1 effect on mu-opioid receptor. In: Brain Research Bulletin. 2013 ; Vol. 90, No. 1. pp. 114-117.
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