Protein kinase C in transmembrane signalling

Anna Farago, Yasutomi Nishizuka

Research output: Contribution to journalReview article

179 Citations (Scopus)

Abstract

Protein kinase C functions as the transducer of a second messenger, diacylglycerol, and is the major receptor for tumour-promoting phorbol esters. The enzyme is a family of proteins with closely but distinct structures and individual enzymological properties. Members of the family are differently distributed in particular cell types and limited intracellular locations from lower organisms to mammalian tissues. The enzyme appears to interact with many signalling pathways, and display functions in the processing and modulation of cellular responses to external stimuli. Presumably, each member of the family plays discrete roles in the control of a variety of membrane functions and activation of gene transcription.

Original languageEnglish
Pages (from-to)350-354
Number of pages5
JournalFEBS letters
Volume268
Issue number2
DOIs
Publication statusPublished - Aug 1 1990

Keywords

  • Protein kinase C, molecular heterogeneity
  • Protein kinase C, signal routes for activation: Protein kinase C down regulation: Protein kinase C. physiological roles
  • Signal transduction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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