Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration

Romana Höftberger, Gabor G. Kovacs, Lidia Sabater, P. Nagy, Gergely Racz, Rosa Miquel, Josep Dalmau, Francesc Graus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Onconeural antibodies are diagnostic markers for paraneoplastic neurological syndromes and indicate the underlying tumor type. Recently, a new antibody against protein-kinase Cγ (PKCγ) was detected in a patient with paraneoplastic cerebellar degeneration (PCD). We report here a second patient. A 70-year-old woman presented with cerebellar ataxia, dysdiadochokinesia, and dysarthria. Her serum showed immunoreactivity against the cytoplasm, dendrites and axons of Purkinje cells in tissue-based screening, later confirmed by immunoblot and phage plaques as anti-PKCγ. Tumor search revealed an adenocarcinoma of hepatobiliary origin. Detection of PKCγ antibodies should be considered in PCD and adenocarcinoma without typical onconeural antibodies.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalJournal of Neuroimmunology
Volume256
Issue number1-2
DOIs
Publication statusPublished - Mar 15 2013

Fingerprint

Paraneoplastic Cerebellar Degeneration
Protein Kinase C
Antibodies
Adenocarcinoma
Paraneoplastic Syndromes
Dysarthria
Cerebellar Ataxia
Purkinje Cells
Dendrites
Bacteriophages
Axons
Neoplasms
Cytoplasm
Serum

Keywords

  • Adenocarcinoma
  • Onconeural antibodies
  • Paraneoplastic cerebellar degeneration
  • PKC gamma

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Höftberger, R., Kovacs, G. G., Sabater, L., Nagy, P., Racz, G., Miquel, R., ... Graus, F. (2013). Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration. Journal of Neuroimmunology, 256(1-2), 91-93. https://doi.org/10.1016/j.jneuroim.2012.12.002

Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration. / Höftberger, Romana; Kovacs, Gabor G.; Sabater, Lidia; Nagy, P.; Racz, Gergely; Miquel, Rosa; Dalmau, Josep; Graus, Francesc.

In: Journal of Neuroimmunology, Vol. 256, No. 1-2, 15.03.2013, p. 91-93.

Research output: Contribution to journalArticle

Höftberger, R, Kovacs, GG, Sabater, L, Nagy, P, Racz, G, Miquel, R, Dalmau, J & Graus, F 2013, 'Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration', Journal of Neuroimmunology, vol. 256, no. 1-2, pp. 91-93. https://doi.org/10.1016/j.jneuroim.2012.12.002
Höftberger, Romana ; Kovacs, Gabor G. ; Sabater, Lidia ; Nagy, P. ; Racz, Gergely ; Miquel, Rosa ; Dalmau, Josep ; Graus, Francesc. / Protein kinase Cγ antibodies and paraneoplastic cerebellar degeneration. In: Journal of Neuroimmunology. 2013 ; Vol. 256, No. 1-2. pp. 91-93.
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