Protein folding

A. Szilágyi, J. Kardos, S. Osváth, L. Barna, P. Závodszky

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

Since Anfinsen's famous experiments in the 1960s, it has been known that the complex three-dimensional structure of protein molecules is encoded in their amino acid sequences, and the chains autonomously fold under proper conditions. Cracking this code, which is sometimes called the second part of the genetic code, has been one of the greatest challenges of molecular biology. Although a full understanding of how proteins fold remains elusive, theoretical and experimental studies of protein folding have come a long way since Anfinsen's findings. In the living cell, folding occurs in a complex and crowded environment, often involving helper proteins, and in some cases it can go awry: the protein can misfold, aggregate, or form amyloid fibers. It is increasingly recognized that misfolded proteins and amyloid formation are the root cause of a number of serious illnesses including several neurodegenerative diseases. Therefore, the study of protein folding remains a key area of biomedical research.

Original languageEnglish
Title of host publicationHandbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function
PublisherSpringer US
Pages303-343
Number of pages41
ISBN (Print)9780387303468
DOIs
Publication statusPublished - 2007

Fingerprint

Protein folding
Protein Folding
Proteins
Neurodegenerative diseases
Genetic Code
Amyloidogenic Proteins
Molecular biology
Amyloid
Neurodegenerative Diseases
Biomedical Research
Molecular Biology
Amino Acid Sequence
Theoretical Models
Cells
Amino Acids
Molecules
Fibers
Experiments

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Szilágyi, A., Kardos, J., Osváth, S., Barna, L., & Závodszky, P. (2007). Protein folding. In Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function (pp. 303-343). Springer US. https://doi.org/10.1007/978-0-387-30379-6_10

Protein folding. / Szilágyi, A.; Kardos, J.; Osváth, S.; Barna, L.; Závodszky, P.

Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, 2007. p. 303-343.

Research output: Chapter in Book/Report/Conference proceedingChapter

Szilágyi, A, Kardos, J, Osváth, S, Barna, L & Závodszky, P 2007, Protein folding. in Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, pp. 303-343. https://doi.org/10.1007/978-0-387-30379-6_10
Szilágyi A, Kardos J, Osváth S, Barna L, Závodszky P. Protein folding. In Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US. 2007. p. 303-343 https://doi.org/10.1007/978-0-387-30379-6_10
Szilágyi, A. ; Kardos, J. ; Osváth, S. ; Barna, L. ; Závodszky, P. / Protein folding. Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function. Springer US, 2007. pp. 303-343
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