The possible participation of protein fluctuation in enzyme activity is considered in this paper. Fluctuation is defined as vibrations, involving collective motion of a large number of atoms in protein molecules. Kinetic and thermodynamic aspects of protein fluctuation and enzyme-ligand interactions are discussed, paying special attention to the influence of electric fields and environmental microviscosity. A brief analysis of available experimental and theoretical data strongly suggests an interrelationship between protein fluctuation and enzyme function.
ASJC Scopus subject areas
- Statistics and Probability
- Modelling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics