Protein expression in metastatic melanoma and the link to disease presentation in a range of tumor phenotypes

Yonghyo Kim, Jeovanis Gil, Indira Pla, Aniel Sanchez, Lazaro Hiram Betancourt, Boram Lee, Roger Appelqvist, Christian Ingvar, Lotta Lundgren, Håkan Olsson, Bo Baldetorp, Ho Jeong Kwon, Henriett Oskolás, Melinda Rezeli, Viktoria Doma, Sarolta Kárpáti, A. Marcell Szasz, István Balázs Németh, Johan Malm, György Marko-Varga

Research output: Contribution to journalArticle

Abstract

Malignant melanoma is among the most aggressive skin cancers and it has among the highest metastatic potentials. Although surgery to remove the primary tumor is the gold standard treatment, once melanoma progresses and metastasizes to the lymph nodes and distal organs, i.e., metastatic melanoma (MM), the usual outcome is decreased survival. To improve survival rates and life span, advanced treatments have focused on the success of targeted therapies in the MAPK pathway that are based on BRAF (BRAF V600E) and MEK. The majority of patients with tumors that have higher expression of BRAF V600E show poorer prognosis than patients with a lower level of the mutated protein. Based on the molecular basis of melanoma, these findings are supported by distinct tumor phenotypes determined from differences in tumor heterogeneity and protein expression profiles. With these aspects in mind, continued challenges are to: (1) deconvolute the complexity and heterogeneity of MM; (2) identify the signaling pathways involved; and (3) determine protein expression to develop targeted therapies. Here, we provide an overview of the results from protein expression in MM and the link to disease presentation in a variety of tumor phenotypes and how these will overcome the challenges of clinical problems and suggest new promising approaches in metastatic melanoma and cancer therapy.

Original languageEnglish
Article number767
JournalCancers
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 2020

Keywords

  • BRAF mutation
  • Clinical proteogenomics
  • Clinical trials
  • Combinative treatments
  • Histopathology
  • Immunotherapy
  • Metastasis signaling pathways
  • Metastatic melanoma
  • Mitochondrial function
  • Targeted therapy
  • Therapeutic opportunities

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Kim, Y., Gil, J., Pla, I., Sanchez, A., Betancourt, L. H., Lee, B., Appelqvist, R., Ingvar, C., Lundgren, L., Olsson, H., Baldetorp, B., Kwon, H. J., Oskolás, H., Rezeli, M., Doma, V., Kárpáti, S., Szasz, A. M., Németh, I. B., Malm, J., & Marko-Varga, G. (2020). Protein expression in metastatic melanoma and the link to disease presentation in a range of tumor phenotypes. Cancers, 12(3), [767]. https://doi.org/10.3390/cancers12030767