Protein dynamics by neutron scattering: The protein dynamical transition and the fragile-to-strong dynamical crossover in hydrated lysozyme

Salvatore Magazù, Federica Migliardo, Antonio Benedetto, Beata Vertessy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In this work Elastic Incoherent Neutron Scattering (EINS) results on lysozyme water mixtures in absence and in presence of bioprotectant systems are presented. The EINS data have been collected by using the IN13 and the IN10 spectrometers at the Institut Laue-Langevin (ILL, Grenoble, France) allowing to evaluate the temperature behaviour of the mean square displacement and of the relaxation time for the investigated systems. The obtained experimental findings together with theoretical calculations allow to put into evidence the role played by the spectrometer resolution and to clarify the connexion between the registered protein dynamical transition, the system relaxation time, and the instrumental energy resolution.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalChemical Physics
Volume424
DOIs
Publication statusPublished - Apr 12 2013

Keywords

  • Bioprotectant
  • Dynamical transition
  • Elastic neutron scattering
  • Lysozyme
  • Mean square displacement
  • Resolution effects
  • Vibrational motion amplitude

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

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