Protein Dynamics as Reported by NMR

Research output: Book/ReportBook

9 Citations (Scopus)

Abstract

Among biomolecules, proteins fulfil the most diverse roles. Recent advances in NMR-spectroscopy demonstrate that these molecules can be characterized by motions on a wide range of time scales, and besides their three-dimensional (3D) structures, dynamics is also fundamental to truly understand their biological activity. The present review focuses on NMR techniques suitable to assess the internal dynamics of proteins from picoseconds to minutes. After a brief introduction of protein motions and different techniques used to capture them, we describe the dynamical aspects of a diverse set of NMR observables in detail. We also present some examples of investigations on various systems aimed to understand Dynamics-Structure-Activity Relationships (DSARs) of proteins.

Original languageEnglish
PublisherUnknown Publisher
Number of pages41
Volume71
EditionC
DOIs
Publication statusPublished - 2010

Publication series

NameAnnual Reports on NMR Spectroscopy
No.C
Volume71
ISSN (Print)00664103

Fingerprint

Nuclear magnetic resonance
proteins
nuclear magnetic resonance
Proteins
Biomolecules
activity (biology)
Bioactivity
Nuclear magnetic resonance spectroscopy
Molecules
spectroscopy
molecules

Keywords

  • Conformational averaging
  • Conformational ensemble
  • Dynamics-Structure-Activity Relationship
  • Internal dynamics
  • NMR observables
  • Protein structure

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

Cite this

Gáspári, Z., & Perczel, A. (2010). Protein Dynamics as Reported by NMR. (C ed.) (Annual Reports on NMR Spectroscopy; Vol. 71, No. C). Unknown Publisher. https://doi.org/10.1016/B978-0-08-089054-8.00002-2

Protein Dynamics as Reported by NMR. / Gáspári, Z.; Perczel, A.

C ed. Unknown Publisher, 2010. 41 p. (Annual Reports on NMR Spectroscopy; Vol. 71, No. C).

Research output: Book/ReportBook

Gáspári, Z & Perczel, A 2010, Protein Dynamics as Reported by NMR. Annual Reports on NMR Spectroscopy, no. C, vol. 71, vol. 71, C edn, Unknown Publisher. https://doi.org/10.1016/B978-0-08-089054-8.00002-2
Gáspári Z, Perczel A. Protein Dynamics as Reported by NMR. C ed. Unknown Publisher, 2010. 41 p. (Annual Reports on NMR Spectroscopy; C). https://doi.org/10.1016/B978-0-08-089054-8.00002-2
Gáspári, Z. ; Perczel, A. / Protein Dynamics as Reported by NMR. C ed. Unknown Publisher, 2010. 41 p. (Annual Reports on NMR Spectroscopy; C).
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