The protein content of 14 rat brain regions and 44 human brain regions was assayed. With the human tissue we compared brain areas from adult with those from aged subjects. In each case tissue was obtained soon after death and was quickly frozen. Although the heterogeneous distribution of many proteins in the brain is well established, unexpectedly the content of protein per unit weight of fresh tissue showed little variation either regionally or with age. It seems that the various regional heterogeneities of proteins cancel each other, resulting in a fairly homogeneous distribution of the total protein content.
ASJC Scopus subject areas
- Geriatrics and Gerontology