Mean proteins concentrations and protein fractions were determined in the serum and lumbar CSF of 69 patients with neuromuscular disorders and 20 healthy subjects. The total protein content of serum and CSF changed in opposite directions in myogenic diseases, particularly in Duchenne muscular dystrophy: in serum there was an elevation and in CSF a decrease. Among the myogenic processes the most remarkable deviations of serum protein fractions were found in Duchenne muscular dystrophy which may indicate a generalized disturbance in protein metabolism. A considerable shift to the left in the CSF protein pattern was observed in peroneal muscular atrophy suggesting the possibility of a barrier disturbance in this group. Simultaneous determination of the protein fractions in serum and CSF may provide a great help for a better understanding of the metabolic properties and pathomechanisms in the neuromuscular processes.
|Number of pages||8|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - Jan 1 1981|
ASJC Scopus subject areas