Protective effects of the inhibition of the renin-angiotensin system against gastric mucosal lesions induced by cold-restraint in the rat

F. Ender, T. Labancz, L. Rosivall

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17 Citations (Scopus)

Abstract

Experiments were designed to examine whether inhibition of the renin-angiotensin system alters gastric mucosal damage in conscious rats subjected io restraint. Two hours immobilization resulted in an ulcer index of 46 ± 4 (n = 16) which was decreased by converting enzyme inhibitor (MK 422, enalaprilat) doses of 1 and 10 mg · kg-1 · h-1 by 50 ± 16 (n = 8) and 66 ± 8% (n = 13), respectively (p <0.05). Gastric blood flow measured by both the 99Tc-labelled frog erythrocytes and 86Rb-clearance methods was low in untreated rats and increased to more than three-fold in angiotensin converting enzyme inhibitor treated animals. Infusion of saralasin a specific angiotensin II receptor blocker (5 μg · kg-1 · h-1, n = 25) also decreased the ulcer index by 40 ± 5% (p <0.05). Thus inhibition of the renin-angiotensin system in conscious cold-restraint rat increased gastric blood flow and reduced mucosal damage. These results suggest that the renin-angiotensin system plays a significant role in the development of expermental gastric ulcer in the cold-restraint model.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalActa Physiologica Hungarica
Volume81
Issue number1
Publication statusPublished - 1993

Fingerprint

Renin-Angiotensin System
Enalaprilat
Stomach
Ulcer
Saralasin
Angiotensin Receptor Antagonists
Enzyme Inhibitors
Stomach Ulcer
Angiotensin-Converting Enzyme Inhibitors
Immobilization
Anura
Erythrocytes

Keywords

  • angiotensin converting enzyme inhibition
  • enalaprilat
  • experimental stress-ulcer
  • gastric blood flow
  • gastric mucosa
  • saralasin

ASJC Scopus subject areas

  • Physiology

Cite this

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abstract = "Experiments were designed to examine whether inhibition of the renin-angiotensin system alters gastric mucosal damage in conscious rats subjected io restraint. Two hours immobilization resulted in an ulcer index of 46 ± 4 (n = 16) which was decreased by converting enzyme inhibitor (MK 422, enalaprilat) doses of 1 and 10 mg · kg-1 · h-1 by 50 ± 16 (n = 8) and 66 ± 8{\%} (n = 13), respectively (p <0.05). Gastric blood flow measured by both the 99Tc-labelled frog erythrocytes and 86Rb-clearance methods was low in untreated rats and increased to more than three-fold in angiotensin converting enzyme inhibitor treated animals. Infusion of saralasin a specific angiotensin II receptor blocker (5 μg · kg-1 · h-1, n = 25) also decreased the ulcer index by 40 ± 5{\%} (p <0.05). Thus inhibition of the renin-angiotensin system in conscious cold-restraint rat increased gastric blood flow and reduced mucosal damage. These results suggest that the renin-angiotensin system plays a significant role in the development of expermental gastric ulcer in the cold-restraint model.",
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AB - Experiments were designed to examine whether inhibition of the renin-angiotensin system alters gastric mucosal damage in conscious rats subjected io restraint. Two hours immobilization resulted in an ulcer index of 46 ± 4 (n = 16) which was decreased by converting enzyme inhibitor (MK 422, enalaprilat) doses of 1 and 10 mg · kg-1 · h-1 by 50 ± 16 (n = 8) and 66 ± 8% (n = 13), respectively (p <0.05). Gastric blood flow measured by both the 99Tc-labelled frog erythrocytes and 86Rb-clearance methods was low in untreated rats and increased to more than three-fold in angiotensin converting enzyme inhibitor treated animals. Infusion of saralasin a specific angiotensin II receptor blocker (5 μg · kg-1 · h-1, n = 25) also decreased the ulcer index by 40 ± 5% (p <0.05). Thus inhibition of the renin-angiotensin system in conscious cold-restraint rat increased gastric blood flow and reduced mucosal damage. These results suggest that the renin-angiotensin system plays a significant role in the development of expermental gastric ulcer in the cold-restraint model.

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