Protective effects of glucosamine-kynurenic acid after compression-induced spinal cord injury in the rat

Andrea Korimová, Dáša Cížková, Jozsef Toldi, László Vécsei, Ivo Vanický

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Kynurenic acid (KYNA), a metabolite of the essential amino acid L-tryptophan, is a broad spectrum antagonist of excitatory amino acid receptors, which have also anticonvulsant and neuroprotective properties. After spinal cord injury (SCI), excitotoxicity is considered to play a significant role in the processes of secondary tissue destruction in both grey and white matter of the spinal cord. In this study, we have tested the potential therapeutic effect of glucosamine-kynurenic acid, administered after experimental compression-induced SCI in the rat. Spinal application of glucosamine-kynurenic acid continually for 24 hr after experimental SCI resulted in improved motor function recovery, beginning from the first week of evaluation and continuing until the end of the study (4 weeks). After 4 weeks' survival, quantitative morphometric analysis of the spinal cord showed that glucosamine-kynurenic acid treatment was associated with improved tissue preservation at the lesion site. These findings indicate that spinal application of glucosaminekynurenic acid is neuroprotective and improves the outcome even when administered after spinal trauma. Our results suggest that the treatments initiated in early posttraumatic period can alleviate secondary injury and improve the final outcome after SCI.

Original languageEnglish
Pages (from-to)996-1004
Number of pages9
JournalCentral European Journal of Biology
Volume7
Issue number6
DOIs
Publication statusPublished - Oct 18 2012

Keywords

  • Excitotoxicity
  • Kynurenic acid
  • NMDA receptor
  • Spinal cord injury

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)

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