Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)

D. Kane, J. C. Lockhart, P. Bálint, C. Mann, W. R. Ferrell, I. B. McInnes

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objective: To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA). Case report: The patient developed arthritis mutilans in all digits of both hands with the exception of the left 4th finger, which had prior sensory denervation following traumatic nerve dissection. Plain radiography, ultrasonography and nerve conduction studies of the hands confirmed the absence of articular disease and sensory innervation in the left 4th digit. Methods: This relationship between joint innervation and joint inflammation was investigated experimentally by prior surgical sensory denervation of the medial aspect of the knee in six Wistar rats in which carrageenan induced arthritis was subsequently induced. Prior sensory denervation-with preservation of muscle function-prevented the development of inflammatory arthritis in the denervated knee. Discussion: Observations in human and animal inflammatory arthritis suggest that regulatory neuroimmune pathways in the joint are an important mechanism that modulates the clinical expression of inflammatory arthritis.

Original languageEnglish
Pages (from-to)325-327
Number of pages3
JournalAnnals of the Rheumatic Diseases
Volume64
Issue number2
DOIs
Publication statusPublished - Feb 2005

Fingerprint

Ultrasonography
Dissection
Carrageenan
Radiography
Denervation
Arthritis
Muscle
Rats
Animals
Joints
Knee
Hand
Inflammation
Psoriatic Arthritis
Neural Conduction
Fingers
Wistar Rats
Muscles

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint). / Kane, D.; Lockhart, J. C.; Bálint, P.; Mann, C.; Ferrell, W. R.; McInnes, I. B.

In: Annals of the Rheumatic Diseases, Vol. 64, No. 2, 02.2005, p. 325-327.

Research output: Contribution to journalArticle

@article{76448c810dea45a996c027bf9e22d4d8,
title = "Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)",
abstract = "Objective: To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA). Case report: The patient developed arthritis mutilans in all digits of both hands with the exception of the left 4th finger, which had prior sensory denervation following traumatic nerve dissection. Plain radiography, ultrasonography and nerve conduction studies of the hands confirmed the absence of articular disease and sensory innervation in the left 4th digit. Methods: This relationship between joint innervation and joint inflammation was investigated experimentally by prior surgical sensory denervation of the medial aspect of the knee in six Wistar rats in which carrageenan induced arthritis was subsequently induced. Prior sensory denervation-with preservation of muscle function-prevented the development of inflammatory arthritis in the denervated knee. Discussion: Observations in human and animal inflammatory arthritis suggest that regulatory neuroimmune pathways in the joint are an important mechanism that modulates the clinical expression of inflammatory arthritis.",
author = "D. Kane and Lockhart, {J. C.} and P. B{\'a}lint and C. Mann and Ferrell, {W. R.} and McInnes, {I. B.}",
year = "2005",
month = "2",
doi = "10.1136/ard.2004.022277",
language = "English",
volume = "64",
pages = "325--327",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",
number = "2",

}

TY - JOUR

T1 - Protective effect of sensory denervation in inflammatory arthritis (evidence of regulatory neuroimmune pathways in the arthritic joint)

AU - Kane, D.

AU - Lockhart, J. C.

AU - Bálint, P.

AU - Mann, C.

AU - Ferrell, W. R.

AU - McInnes, I. B.

PY - 2005/2

Y1 - 2005/2

N2 - Objective: To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA). Case report: The patient developed arthritis mutilans in all digits of both hands with the exception of the left 4th finger, which had prior sensory denervation following traumatic nerve dissection. Plain radiography, ultrasonography and nerve conduction studies of the hands confirmed the absence of articular disease and sensory innervation in the left 4th digit. Methods: This relationship between joint innervation and joint inflammation was investigated experimentally by prior surgical sensory denervation of the medial aspect of the knee in six Wistar rats in which carrageenan induced arthritis was subsequently induced. Prior sensory denervation-with preservation of muscle function-prevented the development of inflammatory arthritis in the denervated knee. Discussion: Observations in human and animal inflammatory arthritis suggest that regulatory neuroimmune pathways in the joint are an important mechanism that modulates the clinical expression of inflammatory arthritis.

AB - Objective: To investigate the direct effect of joint innervation on immune mediated joint inflammation in a patient with psoriatic arthritis (PsA). Case report: The patient developed arthritis mutilans in all digits of both hands with the exception of the left 4th finger, which had prior sensory denervation following traumatic nerve dissection. Plain radiography, ultrasonography and nerve conduction studies of the hands confirmed the absence of articular disease and sensory innervation in the left 4th digit. Methods: This relationship between joint innervation and joint inflammation was investigated experimentally by prior surgical sensory denervation of the medial aspect of the knee in six Wistar rats in which carrageenan induced arthritis was subsequently induced. Prior sensory denervation-with preservation of muscle function-prevented the development of inflammatory arthritis in the denervated knee. Discussion: Observations in human and animal inflammatory arthritis suggest that regulatory neuroimmune pathways in the joint are an important mechanism that modulates the clinical expression of inflammatory arthritis.

UR - http://www.scopus.com/inward/record.url?scp=13244267379&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13244267379&partnerID=8YFLogxK

U2 - 10.1136/ard.2004.022277

DO - 10.1136/ard.2004.022277

M3 - Article

C2 - 15155371

AN - SCOPUS:13244267379

VL - 64

SP - 325

EP - 327

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 2

ER -