Protective effect of prunus cerasus (sour cherry) seed extract on the recovery of ischemia/reperfusion-induced retinal damage in zucker diabetic fatty rat

Balázs Varga, Dániel Priksz, Nóra Lampé, Mariann Bombicz, Andrea Kurucz, Adrienn Mónika Szabó, Anikó Pósa, Renáta Szabó, Ádám Kemény-Beke, Judit Remenyik, Rudolf Gesztelyi, Béla Juhász

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Among diabetes patients, ophthalmological complications are very frequent. High blood glucose and (consequential) ischemia-reperfusion (I/R) injury contribute significantly to the severity of retinopathies. Diabetic retinopathy is among the leading causes of blindness. Our study demonstrates the effect of sour cherry seed extract (SCSE) on blood glucose and function of the retina with electroretinography (ERG) in a diabetic setting with or without ischemia-reperfusion (I/R) injury in Zucker Diabetic Fatty (ZDF) rats. Our results prove that the SCSE has a retinoprotective effect in diabetic rats: according to ERG measurements, SCSE treatment mitigated the retinal function-damaging effect of diabetes, and proved to be protective in the diabetic eye against ischemia-reperfusion injuries of the retina. Outcomes suggest that the protective effects of SCSE may occur through several pathways, including HO-1 dependent mechanisms. The observation that SCSE treatment decreases blood glucose is also novel. These findings offer the possibility for development of novel therapeutic strategies utilizing this emerging functional food, in particular in the prevention of conditions resulting from high blood glucose or I/R injury, such as deterioration of retinal microcirculation.

Original languageEnglish
Article number1782
JournalMolecules
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2017

Keywords

  • Electroretinography
  • Ischemia-reperfusion
  • Prunus cerasus
  • Retina
  • Sour cherry
  • ZDF rat

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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