Protective effect of poly(ADP-ribose) polymerase inhibitors against cell damage induced by antiviral and anticancer drugs

Balázs Sümegi, György Rablóczky, Ildikó Rácz, Kálmán Tory, Sándor Bernáth, Gábor Várbiró, Ferenc Gallyas, Péter Literati Nagy

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Antitumor and antiviral agents have limited selectivity. They kill tumor cells and suppress the proliferation of viruses but can also damage normal tissues. The molecular mechanism of antitumor and antiviral effects relies mainly on specific interactions with the replication process of the tumor cells and the viruses. However, they can induce reactive oxygen species (ROS) formation in the well-oxygenated healthy tissues and activate poly(ADP-ribose) polymerase (PARP). In many cases, oxidative cell damage and PARP activation provide the molecular basis of the dose-limiting side effects of these drugs. The different mechanism of action for the therapeutic and the side effects raises the possibility that nontoxic PARP inhibitors, by protecting normal tissues from the side effect of anticancer and antiviral drugs, may increase the effectiveness and safety of these drugs in a combination therapy.

Original languageEnglish
Title of host publicationCell Death
Subtitle of host publicationThe Role of Poly (ADP-ribose) Polymerase
PublisherCRC Press
Pages167-182
Number of pages16
ISBN (Electronic)9781420038897
ISBN (Print)0849322677, 9780849322679
DOIs
Publication statusPublished - Jan 1 2000

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Sümegi, B., Rablóczky, G., Rácz, I., Tory, K., Bernáth, S., Várbiró, G., Gallyas, F., & Nagy, P. L. (2000). Protective effect of poly(ADP-ribose) polymerase inhibitors against cell damage induced by antiviral and anticancer drugs. In Cell Death: The Role of Poly (ADP-ribose) Polymerase (pp. 167-182). CRC Press. https://doi.org/10.1201/9781420038897