Protective effect of an orally administered, highly potent somatostatin analog (RC-121) against absolute ethanol-induced hemorrhagic erosions of the rat gastric mucosa

F. László, I. Pávó, B. Penke, G. A. Bálint

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14 Citations (Scopus)

Abstract

The cytoprotective effect of a highly potent somatostatin (SRIF) analog, RC-121 (H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), was examined in the absolute ethanol-induced gastric erosion model in rat. This analog diminished the degree of gastric erosion by 50-55% when administered in i.p. doses of 2×10-10-10-8 g/100 g body weight, or in oral doses of 10-8-2×10-7 g/100 body weight. The orally active, highly potent SRIF analogs may be useful as therapeutic agents in the treatment of human peptic ulcer.

Original languageEnglish
Pages (from-to)1573-1578
Number of pages6
JournalLife Sciences
Volume44
Issue number21
DOIs
Publication statusPublished - 1989

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Gastric Mucosa
Somatostatin
Rats
Erosion
Stomach
Ethanol
Body Weight
Peptic Ulcer
RC 121
Mucous Membrane
Therapeutics
TT2-32

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The cytoprotective effect of a highly potent somatostatin (SRIF) analog, RC-121 (H-D-Phe-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-NH2), was examined in the absolute ethanol-induced gastric erosion model in rat. This analog diminished the degree of gastric erosion by 50-55{\%} when administered in i.p. doses of 2×10-10-10-8 g/100 g body weight, or in oral doses of 10-8-2×10-7 g/100 body weight. The orally active, highly potent SRIF analogs may be useful as therapeutic agents in the treatment of human peptic ulcer.",
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T1 - Protective effect of an orally administered, highly potent somatostatin analog (RC-121) against absolute ethanol-induced hemorrhagic erosions of the rat gastric mucosa

AU - László, F.

AU - Pávó, I.

AU - Penke, B.

AU - Bálint, G. A.

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