Protective and destructive immune reactions in apical periodontitis

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Apical periodontitis is initiated primarily by the mixed microflora of infected root canals. Continuous flow of bacteria and their products through the apical foramen induces influx, activation and coordinated interaction of immune-inflammatory cells within the periapical area. Successful mobilization of host defense mechanisms prevents abundant extraradicular bacterial invasion. However, anti-infective effector mechanisms are not restricted to killing the invading microorganisms but also destroy normal tissue components and induce bone absorption, resulting ultimately in the loss of the affected teeth. Moreover, autocrine and paracrine loops of stimulation may lead to the perpetuation of the local inflammatory lesion and may also alter the function of remote tissues and organs. This review attempts to summarize current knowledge about the pathogenic mechanism of apical periodontitis, focusing on the formation of a special granulation tissue that effectively fights bacteria originated from the infected pulp chamber and, by exerting this protective function, also contributes to harmful local and distant events. The dynamic equilibrium between defensive and destructive mechanisms may provide a pathobiological basis for better understanding of clinical signs and symptoms of various forms of apical periodontitis lesions and influence treatment strategy and practice.

Original languageEnglish
Pages (from-to)139-150
Number of pages12
JournalOral Microbiology and Immunology
Volume15
Issue number3
DOIs
Publication statusPublished - Jun 2000

Fingerprint

Periapical Periodontitis
Dental Pulp Cavity
Tooth Apex
Bacteria
Tooth Loss
Granulation Tissue
Signs and Symptoms
Bone and Bones

Keywords

  • Apical periodontitis
  • Bone resorption
  • Focal infection
  • Lymphocytes
  • Phagocytes
  • Root canal flora

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)
  • Dentistry(all)

Cite this

Protective and destructive immune reactions in apical periodontitis. / Márton, I.; Kiss, C.

In: Oral Microbiology and Immunology, Vol. 15, No. 3, 06.2000, p. 139-150.

Research output: Contribution to journalArticle

@article{59be7b798d6c4beeba81602530d834f1,
title = "Protective and destructive immune reactions in apical periodontitis",
abstract = "Apical periodontitis is initiated primarily by the mixed microflora of infected root canals. Continuous flow of bacteria and their products through the apical foramen induces influx, activation and coordinated interaction of immune-inflammatory cells within the periapical area. Successful mobilization of host defense mechanisms prevents abundant extraradicular bacterial invasion. However, anti-infective effector mechanisms are not restricted to killing the invading microorganisms but also destroy normal tissue components and induce bone absorption, resulting ultimately in the loss of the affected teeth. Moreover, autocrine and paracrine loops of stimulation may lead to the perpetuation of the local inflammatory lesion and may also alter the function of remote tissues and organs. This review attempts to summarize current knowledge about the pathogenic mechanism of apical periodontitis, focusing on the formation of a special granulation tissue that effectively fights bacteria originated from the infected pulp chamber and, by exerting this protective function, also contributes to harmful local and distant events. The dynamic equilibrium between defensive and destructive mechanisms may provide a pathobiological basis for better understanding of clinical signs and symptoms of various forms of apical periodontitis lesions and influence treatment strategy and practice.",
keywords = "Apical periodontitis, Bone resorption, Focal infection, Lymphocytes, Phagocytes, Root canal flora",
author = "I. M{\'a}rton and C. Kiss",
year = "2000",
month = "6",
doi = "10.1034/j.1399-302X.2000.150301.x",
language = "English",
volume = "15",
pages = "139--150",
journal = "Molecular Oral Microbiology",
issn = "2041-1006",
publisher = "American Journal of Nursing Company",
number = "3",

}

TY - JOUR

T1 - Protective and destructive immune reactions in apical periodontitis

AU - Márton, I.

AU - Kiss, C.

PY - 2000/6

Y1 - 2000/6

N2 - Apical periodontitis is initiated primarily by the mixed microflora of infected root canals. Continuous flow of bacteria and their products through the apical foramen induces influx, activation and coordinated interaction of immune-inflammatory cells within the periapical area. Successful mobilization of host defense mechanisms prevents abundant extraradicular bacterial invasion. However, anti-infective effector mechanisms are not restricted to killing the invading microorganisms but also destroy normal tissue components and induce bone absorption, resulting ultimately in the loss of the affected teeth. Moreover, autocrine and paracrine loops of stimulation may lead to the perpetuation of the local inflammatory lesion and may also alter the function of remote tissues and organs. This review attempts to summarize current knowledge about the pathogenic mechanism of apical periodontitis, focusing on the formation of a special granulation tissue that effectively fights bacteria originated from the infected pulp chamber and, by exerting this protective function, also contributes to harmful local and distant events. The dynamic equilibrium between defensive and destructive mechanisms may provide a pathobiological basis for better understanding of clinical signs and symptoms of various forms of apical periodontitis lesions and influence treatment strategy and practice.

AB - Apical periodontitis is initiated primarily by the mixed microflora of infected root canals. Continuous flow of bacteria and their products through the apical foramen induces influx, activation and coordinated interaction of immune-inflammatory cells within the periapical area. Successful mobilization of host defense mechanisms prevents abundant extraradicular bacterial invasion. However, anti-infective effector mechanisms are not restricted to killing the invading microorganisms but also destroy normal tissue components and induce bone absorption, resulting ultimately in the loss of the affected teeth. Moreover, autocrine and paracrine loops of stimulation may lead to the perpetuation of the local inflammatory lesion and may also alter the function of remote tissues and organs. This review attempts to summarize current knowledge about the pathogenic mechanism of apical periodontitis, focusing on the formation of a special granulation tissue that effectively fights bacteria originated from the infected pulp chamber and, by exerting this protective function, also contributes to harmful local and distant events. The dynamic equilibrium between defensive and destructive mechanisms may provide a pathobiological basis for better understanding of clinical signs and symptoms of various forms of apical periodontitis lesions and influence treatment strategy and practice.

KW - Apical periodontitis

KW - Bone resorption

KW - Focal infection

KW - Lymphocytes

KW - Phagocytes

KW - Root canal flora

UR - http://www.scopus.com/inward/record.url?scp=0343674543&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343674543&partnerID=8YFLogxK

U2 - 10.1034/j.1399-302X.2000.150301.x

DO - 10.1034/j.1399-302X.2000.150301.x

M3 - Article

C2 - 11154396

AN - SCOPUS:0343674543

VL - 15

SP - 139

EP - 150

JO - Molecular Oral Microbiology

JF - Molecular Oral Microbiology

SN - 2041-1006

IS - 3

ER -