Protection of Wistar Furth rats from chronic renal disease is associated with maintained renal nitric oxide synthase

Aaron Erdely, L. Wágner, V. Müller, Attila Szabo, Chris Baylis

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59 Citations (Scopus)

Abstract

Wistar Furth (WF) rats do not develop renal injury after severe reduction of renal mass. Because clinical and animal studies suggested that nitric oxide (NO) deficiency occurs and may contribute to chronic renal disease (CRD), the status of the NO system in WF versus Sprague Dawley (SD) rats was examined with the 5/6 renal ablation/infarction (A/I) model of CRD. Eleven weeks after A/I, SD rats developed proteinuria, severe kidney damage, decreased renal function, and marked decreases in total and renal NO synthase (NOS), specifically neuronal NOS. In contrast, WF rats exhibited elevated baseline and maintained post-A/I total NO production, with no decrease in renal cortex NOS activity despite a decrease in remnant neuronal NOS abundance. When low-dose chronic Nω-nitro-L-arginine methyl ester treatment was added for WF A/I-treated rats, rapid progression of CRD was observed. In conclusion, elevated NO production in WF rats was associated with protection from the progression of CRD after renal mass reduction. The protection might be attributable to greater total and renal NO-generating capacity and increased nephron number, compared with SD rats. NOS inhibition rendered WF rats susceptible to progression, suggesting a possible critical threshold for NO production, below which renal injury occurs.

Original languageEnglish
Pages (from-to)2526-2533
Number of pages8
JournalJournal of the American Society of Nephrology
Volume14
Issue number10
DOIs
Publication statusPublished - Oct 1 2003

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Inbred WF Rats
Chronic Renal Insufficiency
Nitric Oxide Synthase
Kidney
Nitric Oxide
Infarction
Sprague Dawley Rats
Nitric Oxide Synthase Type I
Nephrons
Wounds and Injuries
Proteinuria

ASJC Scopus subject areas

  • Nephrology

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Protection of Wistar Furth rats from chronic renal disease is associated with maintained renal nitric oxide synthase. / Erdely, Aaron; Wágner, L.; Müller, V.; Szabo, Attila; Baylis, Chris.

In: Journal of the American Society of Nephrology, Vol. 14, No. 10, 01.10.2003, p. 2526-2533.

Research output: Contribution to journalArticle

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