Protection against anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade

G. Lazar, Jr George Lázár, J. Kaszaki, J. Oláh, Elizabeth Husztik

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Data in the literature concerning the role of Kupffer cells in anaphylaxis are contradictory. In the present study the effect of Kupffer cell blockade induced by gadolinium chloride (GdCl3) on anaphylactic shock was investigated. Our observations show that GdCl3 prevents lethal anaphylactic shock in mice sensitized to ovalbumin. Gadolinium chloride given i.v. in a dose of 1 mg (100 g)-1 body weight 24 or 48 h before the elicitation of anaphylactic shock resulted in 80% survival, compared with the 43% survival in the control group. The same dose of gadolinium chlorde and also other rare earth metal salts, like lanthanum-, praseodymium-, neodymium-, and european chlorides given i.v., one day before the elicitation of anaphylactic shock, greatly reduced the mortality in mice sensitized with ovalbumin and Bordatella pertussis vaccine. However, gadolinium chloride given, per os, in a dose of 2 mg (100 g)-1 body weight, one or two days before the elicitation of anaphylactic shock were ineffective. Gadolinum chloride similarly abrogated the symptoms of anaphylaxis, including the accumulation of serotonin and histamine in the liver. The results suggest that Kupffer cells play an important role in mouse anaphylaxis.

Original languageEnglish
Pages (from-to)619-622
Number of pages4
JournalJournal of Alloys and Compounds
Volume225
Issue number1-2
DOIs
Publication statusPublished - Jul 15 1995

Fingerprint

Gadolinium
Ovalbumin
Chlorides
Praseodymium
Rare Earth Metals
Pertussis Vaccine
Neodymium
Lanthanum
Liver
Histamine
Vaccines
Serotonin
Salts
Rare earths
gadolinium chloride
Kupffer Cells
Metals

Keywords

  • Anaphyalaxis
  • f-Elements
  • Gadolinium chloride
  • Kupffer cell
  • Kupffer cell blockade

ASJC Scopus subject areas

  • Mechanical Engineering
  • Mechanics of Materials
  • Materials Chemistry
  • Metals and Alloys

Cite this

Protection against anaphylactic shock by gadolinium chloride-induced Kupffer cell blockade. / Lazar, G.; George Lázár, Jr; Kaszaki, J.; Oláh, J.; Husztik, Elizabeth.

In: Journal of Alloys and Compounds, Vol. 225, No. 1-2, 15.07.1995, p. 619-622.

Research output: Contribution to journalArticle

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