Prostaglandins, norepinephrine, angiotensin II and blood pressure changes induced by uteroplacental ischemia in rabbits

G. Losonczy, H. Todd, D. C. Palmer, F. Hertelendy

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Infrarenal aortic constriction was performed on pregnant rabbits on the 21st day of gestation, and the ensuing responses to uteroplacental ischemia were compared to sham-operated pregnant and constricted nonpregnant rabbits. Aortic constriction in pregnant animals induced hypertension (25-41% rise), proteinuria, thrombocytopenia (40% decrease), hypovolemia, decreased packed cell volume and fetal growth retardation. Renal fibrin deposition was demonstrated in the glomerular mesangium. In addition, pressor responsiveness to the administration of both angiotensin II and norepinephrine was increased. Correlation of higher plasma norepinephrine content with blood pressure suggests that an αadrenergic mechanism is activated by the ischemia of the pregnant uterus. Veins draining ischemic uteroplacental tissues contained 2.5 and 2 fold higher amounts of angiotensin II and PGE2 respectively. Because arterial levels of these substances either decreased or remained unchanged, it is suggested that they may have induced local vasodilation rather than having exerted an influence on systemic hemodynamics

Original languageEnglish
Pages (from-to)271-293
Number of pages23
JournalHypertension in Pregnancy
Issue number3
Publication statusPublished - Jan 1 1986


ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynaecology

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