Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver

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Abstract

Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP-D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time interleukin-1 (IL-1) production in perfused liver rose markedly upon the addition of FDP-D. It is suggested that prostaglandins are not involved in the effects of FDP-D on the liver. The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels.

Original languageEnglish
Pages (from-to)269-271
Number of pages3
JournalScandinavian Journal of Immunology
Volume48
Issue number3
DOIs
Publication statusPublished - 1998

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Fibrinogen
Prostaglandins
Interleukin-6
Liver
Interleukin-1
Prostaglandin D2
Dinoprostone
Endotoxins
Indomethacin
formycin diphosphate

ASJC Scopus subject areas

  • Immunology

Cite this

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title = "Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver",
abstract = "Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP-D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time interleukin-1 (IL-1) production in perfused liver rose markedly upon the addition of FDP-D. It is suggested that prostaglandins are not involved in the effects of FDP-D on the liver. The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels.",
author = "M. Csala and I. L{\'e}r{\'a}nt and G. B{\'a}nhegyi and T. Kardon and F. Pusk{\'a}s and I. Much{\'a} and R. Machovich and A. Falus and J. Mandl",
year = "1998",
doi = "10.1046/j.1365-3083.1998.00395.x",
language = "English",
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pages = "269--271",
journal = "Scandinavian Journal of Immunology",
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TY - JOUR

T1 - Prostaglandin-independent stimulation of interleukin-6 production by fibrinogen degradation product D in perfused murine liver

AU - Csala, M.

AU - Léránt, I.

AU - Bánhegyi, G.

AU - Kardon, T.

AU - Puskás, F.

AU - Muchá, I.

AU - Machovich, R.

AU - Falus, A.

AU - Mandl, J.

PY - 1998

Y1 - 1998

N2 - Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP-D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time interleukin-1 (IL-1) production in perfused liver rose markedly upon the addition of FDP-D. It is suggested that prostaglandins are not involved in the effects of FDP-D on the liver. The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels.

AB - Bacterial endotoxin (LPS) and fibrinogen degradation product D (FDP-D) are both potent stimulators of interleukin-6 (IL-6) production in liver, however, there are differences in their metabolic effects. The aim of the present study was to compare the role of prostaglandins in the enhancement of IL-6 production by LPS or FDP-D in perfused mouse livers. Indomethacin inhibited the effect of LPS significantly but was ineffective in the case of FDP-D. Accordingly, production of prostaglandins D2 and E2 was not elevated following the addition of FDP-D, while their formation was increased several fold by LPS. At the same time interleukin-1 (IL-1) production in perfused liver rose markedly upon the addition of FDP-D. It is suggested that prostaglandins are not involved in the effects of FDP-D on the liver. The stimulatory effect of FDP-P on IL-6 production might be the consequence of elevated IL-1 levels.

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JO - Scandinavian Journal of Immunology

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