Prostaglandin fand prostacyclin tissue levels in early phases of trypsin-induced acute pancreatitis in rats

Zoltan Berger, Gabor A. Balint, A. Pap, Gizella Karacsony, Vince Varro

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Local variations of prostaglandin (PG) I2 and F2„ were studied in the pancreatic tissue during the first hour of an acute experimental necro-hemorrhagic pancreatitis. The local pancreatitis was induced by trypsin injection into the interstitium of the splenic part of rat pancreas, and a saline injection was given into the interstitium in the duodenal part of the same pancreas as control. PGF2CI level was measured by specific radioimmunoassay (RIA), and the stable degradation product of PGI2, the 6-keto-PGFia, was determined also by RIA as an index of PGI2 level. The results were compared between the two regions and with control intact pancreata. The PGI2 level transiently decreased, whereas the PGF2„ increased in the region of localized hemorrhagic pancreatitis when compared with the intact pancreata. By contrast, the quickly disappearing edematous reaction induced by saline injection was accompanied by opposite changes in the two PGs studied: PGI2 was transiently elevated and PGF2„ diminished. In consequence, the ratio of the two PGs was shifted in favor of PGI2 in a transient edematous reaction and in favor of PGF2„ in hemorrhagic pancreatitis. It was concluded that PGI2 plays some protective role while PGF2a might be one of the aggressive mediators in the inflammatory process. Their biological importance must be limited since PGF2c[ alone did not induce pancreatitis nor did PGI2 protect against the trypsin-induced local pancreatitis.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalPancreas.
Volume4
Issue number3
Publication statusPublished - 1989

Fingerprint

Epoprostenol
Pancreatitis
Trypsin
Prostaglandins
Dinoprost
Pancreas
Injections
Radioimmunoassay

Keywords

  • Inflammatory process
  • Pancreatitis
  • Prostaglandins I2 and F2o[

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Internal Medicine
  • Gastroenterology

Cite this

Prostaglandin fand prostacyclin tissue levels in early phases of trypsin-induced acute pancreatitis in rats. / Berger, Zoltan; Balint, Gabor A.; Pap, A.; Karacsony, Gizella; Varro, Vince.

In: Pancreas., Vol. 4, No. 3, 1989, p. 295-299.

Research output: Contribution to journalArticle

Berger, Z, Balint, GA, Pap, A, Karacsony, G & Varro, V 1989, 'Prostaglandin fand prostacyclin tissue levels in early phases of trypsin-induced acute pancreatitis in rats', Pancreas., vol. 4, no. 3, pp. 295-299.
Berger, Zoltan ; Balint, Gabor A. ; Pap, A. ; Karacsony, Gizella ; Varro, Vince. / Prostaglandin fand prostacyclin tissue levels in early phases of trypsin-induced acute pancreatitis in rats. In: Pancreas. 1989 ; Vol. 4, No. 3. pp. 295-299.
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