Prostaglandin E2: Actions on the circular and longitudinal contractions of the canine colon

T. Wittmann, O. Sanches, A. Lambert, G. Buliard, J. F. Grenier

Research output: Contribution to journalArticle

Abstract

The effect of prostaglandin E2 (PGE2) on the circular and longitudinal contractions of the canine colon was studied in chronic conditions. A mechanical transducer capable of recording simultaneously the variations of length in two perpendicular directions at 90°to each other was developed and implanted on the canine colon 10 cm distal to the ileocaecal junction. The recording sessions started on the 6th postoperative day. The colonic motility was recorded two hours before (control period) and two hours after the intravenous injection of PGE2 in three different doses (0.1, 1.0 and 10 μg/kg). Two sorts of mechanical activity were identified: contractile phases (mean duration: 8.8 min for longitudinal and 6.7 min for circular contractions) and sporadic contractions (mean duration: 0.37 min for longitudinal and 0.28 min for circular contractions). PGE2 in the three different doses used induces an important reduction in the duration and in the amplitude of the circular contractions. These reductions become important only in the 2nd hour after the injection of PGE2. The duration of the longitudinal contractions was modified by 10 μg/kg of PGE2, provoking an important and immediate increase of this value. Although the amplitude of longitudinal contractions remains constant, each dose of PGE2 induces strong premature bursts of longitudinal colonic contractions. It is concluded that PGE2 has a regulating effect on colonic motility, even at small doses, with a different action on the two muscular layers. According to the dose used, it leads to hypokinesia (relaxation) in the circular and to strong contractions in the longitudinal colonic muscles.

Original languageEnglish
Pages (from-to)67-76
Number of pages10
JournalInflammopharmacology
Volume5
Issue number1
Publication statusPublished - 1997

Fingerprint

Dinoprostone
Canidae
Colon
Hypokinesia
Transducers
Intravenous Injections
Muscles
Injections

Keywords

  • colon
  • motility
  • prostaglandins

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Wittmann, T., Sanches, O., Lambert, A., Buliard, G., & Grenier, J. F. (1997). Prostaglandin E2: Actions on the circular and longitudinal contractions of the canine colon. Inflammopharmacology, 5(1), 67-76.

Prostaglandin E2 : Actions on the circular and longitudinal contractions of the canine colon. / Wittmann, T.; Sanches, O.; Lambert, A.; Buliard, G.; Grenier, J. F.

In: Inflammopharmacology, Vol. 5, No. 1, 1997, p. 67-76.

Research output: Contribution to journalArticle

Wittmann, T, Sanches, O, Lambert, A, Buliard, G & Grenier, JF 1997, 'Prostaglandin E2: Actions on the circular and longitudinal contractions of the canine colon', Inflammopharmacology, vol. 5, no. 1, pp. 67-76.
Wittmann, T. ; Sanches, O. ; Lambert, A. ; Buliard, G. ; Grenier, J. F. / Prostaglandin E2 : Actions on the circular and longitudinal contractions of the canine colon. In: Inflammopharmacology. 1997 ; Vol. 5, No. 1. pp. 67-76.
@article{2de06af0e78046c4bacbb88382aee0ad,
title = "Prostaglandin E2: Actions on the circular and longitudinal contractions of the canine colon",
abstract = "The effect of prostaglandin E2 (PGE2) on the circular and longitudinal contractions of the canine colon was studied in chronic conditions. A mechanical transducer capable of recording simultaneously the variations of length in two perpendicular directions at 90°to each other was developed and implanted on the canine colon 10 cm distal to the ileocaecal junction. The recording sessions started on the 6th postoperative day. The colonic motility was recorded two hours before (control period) and two hours after the intravenous injection of PGE2 in three different doses (0.1, 1.0 and 10 μg/kg). Two sorts of mechanical activity were identified: contractile phases (mean duration: 8.8 min for longitudinal and 6.7 min for circular contractions) and sporadic contractions (mean duration: 0.37 min for longitudinal and 0.28 min for circular contractions). PGE2 in the three different doses used induces an important reduction in the duration and in the amplitude of the circular contractions. These reductions become important only in the 2nd hour after the injection of PGE2. The duration of the longitudinal contractions was modified by 10 μg/kg of PGE2, provoking an important and immediate increase of this value. Although the amplitude of longitudinal contractions remains constant, each dose of PGE2 induces strong premature bursts of longitudinal colonic contractions. It is concluded that PGE2 has a regulating effect on colonic motility, even at small doses, with a different action on the two muscular layers. According to the dose used, it leads to hypokinesia (relaxation) in the circular and to strong contractions in the longitudinal colonic muscles.",
keywords = "colon, motility, prostaglandins",
author = "T. Wittmann and O. Sanches and A. Lambert and G. Buliard and Grenier, {J. F.}",
year = "1997",
language = "English",
volume = "5",
pages = "67--76",
journal = "Inflammopharmacology",
issn = "0925-4692",
publisher = "Birkhauser Verlag Basel",
number = "1",

}

TY - JOUR

T1 - Prostaglandin E2

T2 - Actions on the circular and longitudinal contractions of the canine colon

AU - Wittmann, T.

AU - Sanches, O.

AU - Lambert, A.

AU - Buliard, G.

AU - Grenier, J. F.

PY - 1997

Y1 - 1997

N2 - The effect of prostaglandin E2 (PGE2) on the circular and longitudinal contractions of the canine colon was studied in chronic conditions. A mechanical transducer capable of recording simultaneously the variations of length in two perpendicular directions at 90°to each other was developed and implanted on the canine colon 10 cm distal to the ileocaecal junction. The recording sessions started on the 6th postoperative day. The colonic motility was recorded two hours before (control period) and two hours after the intravenous injection of PGE2 in three different doses (0.1, 1.0 and 10 μg/kg). Two sorts of mechanical activity were identified: contractile phases (mean duration: 8.8 min for longitudinal and 6.7 min for circular contractions) and sporadic contractions (mean duration: 0.37 min for longitudinal and 0.28 min for circular contractions). PGE2 in the three different doses used induces an important reduction in the duration and in the amplitude of the circular contractions. These reductions become important only in the 2nd hour after the injection of PGE2. The duration of the longitudinal contractions was modified by 10 μg/kg of PGE2, provoking an important and immediate increase of this value. Although the amplitude of longitudinal contractions remains constant, each dose of PGE2 induces strong premature bursts of longitudinal colonic contractions. It is concluded that PGE2 has a regulating effect on colonic motility, even at small doses, with a different action on the two muscular layers. According to the dose used, it leads to hypokinesia (relaxation) in the circular and to strong contractions in the longitudinal colonic muscles.

AB - The effect of prostaglandin E2 (PGE2) on the circular and longitudinal contractions of the canine colon was studied in chronic conditions. A mechanical transducer capable of recording simultaneously the variations of length in two perpendicular directions at 90°to each other was developed and implanted on the canine colon 10 cm distal to the ileocaecal junction. The recording sessions started on the 6th postoperative day. The colonic motility was recorded two hours before (control period) and two hours after the intravenous injection of PGE2 in three different doses (0.1, 1.0 and 10 μg/kg). Two sorts of mechanical activity were identified: contractile phases (mean duration: 8.8 min for longitudinal and 6.7 min for circular contractions) and sporadic contractions (mean duration: 0.37 min for longitudinal and 0.28 min for circular contractions). PGE2 in the three different doses used induces an important reduction in the duration and in the amplitude of the circular contractions. These reductions become important only in the 2nd hour after the injection of PGE2. The duration of the longitudinal contractions was modified by 10 μg/kg of PGE2, provoking an important and immediate increase of this value. Although the amplitude of longitudinal contractions remains constant, each dose of PGE2 induces strong premature bursts of longitudinal colonic contractions. It is concluded that PGE2 has a regulating effect on colonic motility, even at small doses, with a different action on the two muscular layers. According to the dose used, it leads to hypokinesia (relaxation) in the circular and to strong contractions in the longitudinal colonic muscles.

KW - colon

KW - motility

KW - prostaglandins

UR - http://www.scopus.com/inward/record.url?scp=0031056442&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031056442&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031056442

VL - 5

SP - 67

EP - 76

JO - Inflammopharmacology

JF - Inflammopharmacology

SN - 0925-4692

IS - 1

ER -