Prostacyclin mediates antiaggregatory and hypotensive actions of endothelin in anaesthetized beagle dogs

F. Herman, K. Magyar, P. E. Chabrier, P. Braquet, J. Filep

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

The effects of endothelin on blood pressure and in vivo aggregation of platelets were studied in anaesthetized beagle dogs. Intravenous administration of endothelin (0.03-0.3 nmol kg-1) resulted in a dose-dependent transient hypotension followed by a long-lasting hypertension and inhibition of platelet aggregation. These changes were accompanied by dose-dependent elevation of plasma 6-keto prostaglandin F(1α) levels. Pretreatment of the animals with acetylsalicylic acid significantly attenuated both the vascular and antiaggregatory responses to endothelin. These data provide evidence for in vivo release of prostacyclin by endothelin in anaesthetized dogs.

Original languageEnglish
Pages (from-to)38-40
Number of pages3
JournalBritish journal of pharmacology
Volume98
Issue number1
DOIs
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Prostacyclin mediates antiaggregatory and hypotensive actions of endothelin in anaesthetized beagle dogs'. Together they form a unique fingerprint.

  • Cite this