Prostacyclin and prostagladin synthesis in isolated brain capillaries

Á Gecse, Anna Ottlecz, Zsófia Mezei, G. Telegdy, F. Joó, E. Dux, Irina Karnushina

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Abstract

The synthesis of prostacyclin and prostaglandins was examined in isolated blood-free brain capillaries of guinea-pigs and rats using 1-14C-arachidonic acid as a precursor. The main prostaglandins synthesized by guinea-pig microvessels were prostaglandin D2 and prostaglandin E2. Substantially less prostaglandin F2α or the prostacyclin stable metabolite, 6-oxo-prostaglandin F1α was synthesized. Rat capillary prostaglandin distribution differed substantially from that of the guinea-pigs although the principle prostaglandin was also PGD2. Total prostaglandin conversion was greater in guinea-pig capillaries than in the rat. Norepinephrine stimulated the prostaglandin forming capacity of blood free cerebral microvasculature of guinea-pigs. Prostacyclin and prostaglandins could be involved in the activity dependent regulation of regional cerebral blood flow and permeability.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalProstaglandins
Volume23
Issue number3
DOIs
Publication statusPublished - Mar 1982

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Gecse, Á., Ottlecz, A., Mezei, Z., Telegdy, G., Joó, F., Dux, E., & Karnushina, I. (1982). Prostacyclin and prostagladin synthesis in isolated brain capillaries. Prostaglandins, 23(3), 287-297. https://doi.org/10.1016/0090-6980(82)90074-0