Prospective, randomized, multicenter evaluation of a polyethylene terephthalate micronet mesh-covered stent (MGuard) in ST-segment elevation myocardial infarction: The MASTER trial

Gregg W. Stone, Alexandre Abizaid, Sigmund Silber, Jose M. Dizon, B. Merkely, Ricardo A. Costa, Ran Kornowski, Andrea Abizaid, Roman Wojdya, Akiko Maehara, Ovidiu Dressler, Sorin J. Brener, Eli Bar, Dariusz Dudek

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objectives: This study sought to evaluate the potential utility of a novel polyethylene terephthalate micronet mesh-covered stent (MGuard) in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI). Background: Suboptimal myocardial reperfusion after PCI in STEMI is common and results in increased infarct size and mortality. The MGuard is a novel thin-strut metal stent with a polyethylene terephthalate micronet covering designed to trap and exclude thrombus and friable atheromatous debris to prevent distal embolization. Methods: A total of 433 patients with STEMI presenting within 12 h of symptom onset undergoing PCI were randomized at 50 sites in 9 countries to the MGuard (n = 217) or commercially available bare metal or drug-eluting stents (n = 216). The primary endpoint was the rate of complete (

Original languageEnglish
Pages (from-to)1975-1984
Number of pages10
JournalJournal of the American College of Cardiology
Volume60
Issue number19
DOIs
Publication statusPublished - Nov 6 2012

Fingerprint

Polyethylene Terephthalates
Percutaneous Coronary Intervention
Stents
Metals
Myocardial Infarction
Myocardial Reperfusion
Drug-Eluting Stents
Thrombosis
Mortality
ST Elevation Myocardial Infarction

Keywords

  • embolic protection
  • myocardial infarction
  • reperfusion

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

Cite this

Prospective, randomized, multicenter evaluation of a polyethylene terephthalate micronet mesh-covered stent (MGuard) in ST-segment elevation myocardial infarction : The MASTER trial. / Stone, Gregg W.; Abizaid, Alexandre; Silber, Sigmund; Dizon, Jose M.; Merkely, B.; Costa, Ricardo A.; Kornowski, Ran; Abizaid, Andrea; Wojdya, Roman; Maehara, Akiko; Dressler, Ovidiu; Brener, Sorin J.; Bar, Eli; Dudek, Dariusz.

In: Journal of the American College of Cardiology, Vol. 60, No. 19, 06.11.2012, p. 1975-1984.

Research output: Contribution to journalArticle

Stone, GW, Abizaid, A, Silber, S, Dizon, JM, Merkely, B, Costa, RA, Kornowski, R, Abizaid, A, Wojdya, R, Maehara, A, Dressler, O, Brener, SJ, Bar, E & Dudek, D 2012, 'Prospective, randomized, multicenter evaluation of a polyethylene terephthalate micronet mesh-covered stent (MGuard) in ST-segment elevation myocardial infarction: The MASTER trial', Journal of the American College of Cardiology, vol. 60, no. 19, pp. 1975-1984. https://doi.org/10.1016/j.jacc.2012.09.004
Stone, Gregg W. ; Abizaid, Alexandre ; Silber, Sigmund ; Dizon, Jose M. ; Merkely, B. ; Costa, Ricardo A. ; Kornowski, Ran ; Abizaid, Andrea ; Wojdya, Roman ; Maehara, Akiko ; Dressler, Ovidiu ; Brener, Sorin J. ; Bar, Eli ; Dudek, Dariusz. / Prospective, randomized, multicenter evaluation of a polyethylene terephthalate micronet mesh-covered stent (MGuard) in ST-segment elevation myocardial infarction : The MASTER trial. In: Journal of the American College of Cardiology. 2012 ; Vol. 60, No. 19. pp. 1975-1984.
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