Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer

Renáta Bor, Béla Vasas, Anna Fábián, Anita Bálint, Klaudia Farkas, Ágnes Milassin, L. Czakó, Mariann Rutka, T. Molnár, Mónika Szucs, L. Tiszlavicz, László Kaizer, Sándor Hamar, Zoltán Szepes

Research output: Contribution to journalArticle

Abstract

Background: The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods: To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results: EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3%). Diagnostic yield was 67.4% in the SS and 65.2% in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8% vs. 30.0%; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100% vs. 73.5, 100%). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7%). Conclusion: The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective.

Original languageEnglish
Article number6
JournalBMC Gastroenterology
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 9 2019

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Endoscopic Ultrasound-Guided Fine Needle Aspiration
Suction
Pancreatic Neoplasms
Retrospective Studies
Costs and Cost Analysis
Sensitivity and Specificity

Keywords

  • Endoscopic ultrasound
  • Endosonography
  • EUS-FNA
  • Pancreatic cancer
  • Sampling

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer. / Bor, Renáta; Vasas, Béla; Fábián, Anna; Bálint, Anita; Farkas, Klaudia; Milassin, Ágnes; Czakó, L.; Rutka, Mariann; Molnár, T.; Szucs, Mónika; Tiszlavicz, L.; Kaizer, László; Hamar, Sándor; Szepes, Zoltán.

In: BMC Gastroenterology, Vol. 19, No. 1, 6, 09.01.2019.

Research output: Contribution to journalArticle

Bor, Renáta ; Vasas, Béla ; Fábián, Anna ; Bálint, Anita ; Farkas, Klaudia ; Milassin, Ágnes ; Czakó, L. ; Rutka, Mariann ; Molnár, T. ; Szucs, Mónika ; Tiszlavicz, L. ; Kaizer, László ; Hamar, Sándor ; Szepes, Zoltán. / Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer. In: BMC Gastroenterology. 2019 ; Vol. 19, No. 1.
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abstract = "Background: The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods: To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results: EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3{\%}). Diagnostic yield was 67.4{\%} in the SS and 65.2{\%} in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8{\%} vs. 30.0{\%}; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100{\%} vs. 73.5, 100{\%}). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7{\%}). Conclusion: The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective.",
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T1 - Prospective comparison of slow-pull and standard suction techniques of endoscopic ultrasound-guided fine needle aspiration in the diagnosis of solid pancreatic cancer

AU - Bor, Renáta

AU - Vasas, Béla

AU - Fábián, Anna

AU - Bálint, Anita

AU - Farkas, Klaudia

AU - Milassin, Ágnes

AU - Czakó, L.

AU - Rutka, Mariann

AU - Molnár, T.

AU - Szucs, Mónika

AU - Tiszlavicz, L.

AU - Kaizer, László

AU - Hamar, Sándor

AU - Szepes, Zoltán

PY - 2019/1/9

Y1 - 2019/1/9

N2 - Background: The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods: To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results: EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3%). Diagnostic yield was 67.4% in the SS and 65.2% in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8% vs. 30.0%; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100% vs. 73.5, 100%). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7%). Conclusion: The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective.

AB - Background: The usage of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for the diagnosis of solid pancreatic cancer is increasing, however mainly retrospective studies are available about the detailed methods of sampling. Methods: To compare prospectively the diagnostic yield of EUS-FNA samples obtained with slow-pull (SP) and with standard suction technique (SS). Results: EUS-FNA sampling was diagnostic in 72 of 92 cases (78.3%). Diagnostic yield was 67.4% in the SS and 65.2% in the SP group. The number of smear pairs (1.84 vs. 3.56; p < 0.001) and blood contamination (1.50 vs. 2.19; p < 0.001) were significantly higher in the SS group, which resulted in lower rate of diagnostic samples (41.8% vs. 30.0%; p = 0.003). There was no difference in the cellularity (1.58 vs. 1.37; p = 0.2554), or in the sensitivity and specificity in the identification of malignancy between SP and SS subgroups (69.9, 100% vs. 73.5, 100%). Histological samples were obtained in 60 cases (with SP: 49 cases; with SS: 46 cases). There was no difference in the diagnostic yield of histological samples between the groups (63 and 58.7%). Conclusion: The diagnostic yield, the cellularity of smears and the rate of acquiring sufficient histological material are similar in the SP and SS group, but due to lower bloodiness and decreased number of slides, the pathological diagnosis is faster and more cost-effective.

KW - Endoscopic ultrasound

KW - Endosonography

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KW - Pancreatic cancer

KW - Sampling

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