Az antioxidáns védekezóképesség prospektív, biokémiai vizsgálata retinopathia preamaturorumban.

Translated title of the contribution: Prospective biochemical study of the antioxidant defense capacity in retinopathy of prematurity

A. Papp, I. Németh, Z. Pelle, P. Tekulics

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The study was carried out on 60 oxygen-treated premature infants weighed less than 2000 g (1529 +/- 302 g, x mean +/- S. D.) and on their mothers. Both the Retinopathy of Prematurity screening and the biochemical tests were started at the age of 6 weeks. According to our results, the signs of an acute oxidative stress could be seen in all 60 oxygen-treated prematures erythrocyte's glutathione redox system, independently of the presence of the retinopathy compared to prematures (n = 20) with the same gestational age but without oxygen therapy (1720 +/- 305 g, mean +/- S.D.). The concentrations of free sulfhydril groups in the plasma, and the blood selenium levels were significantly lower in the prematures suffering from moderate retinopathy (n = 5) than in the other oxygen-treated premature without retinopathy (n = 27) and with "any retinopathy" (n = 28) patients groups. The same tendency was seen in the mothers. Vitamin E treatment of "any retinopathy" infants seemed to have a positive effect against the development of Retinopathy of Prematurity. The close correlation found between the antioxidant capacity of the mothers and babies suggest that the supplementation of feeding with sulfur-containing amino acids (methionine, cysteine) during pregnancy would improve the antioxidant capacity of prematures. An antioxidant cocktail (selenium + vitamin E) given to the high-risk mothers (advanced age, smoking, pregnancy-induced hypertension) before delivery as suggested in literature might be useful in prevention of Retinopathy of Prematurity.

Translated title of the contributionProspective biochemical study of the antioxidant defense capacity in retinopathy of prematurity
Original languageHungarian
Pages (from-to)201-205
Number of pages5
JournalOrvosi hetilap
Volume138
Issue number4
Publication statusPublished - Jan 26 1997

ASJC Scopus subject areas

  • Medicine(all)

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