Proposal of a Dukes-MAC-like staging system for gastric cancer

Simona Gurzu, Haruhiko Sugimura, Janina Orlowska, Janos Szederjesi, Zoltan Szentirmay, Tivadar Bara, Ananmaria Fetyko, Ioan Jung

Research output: Contribution to journalArticle

2 Citations (Scopus)


The aim of this study was to present an epidemiological update regarding the classical prognostic parameters of gastric cancer (GC) in 3 countries from Eastern Europe and to suggest a modification of the pTNM staging system. In 333 consecutive cases which were diagnosed between 2003 and 2012 in 3 departments of pathology from Romania, Hungary, and Poland, the following parameters were analyzed: age and gender of patients, tumor localization, macroscopic and microscopic aspects including the degree of discohesivity, depth of tumor infiltration, and pTNM stage. From all of the studied parameters, the following proved to have independent prognostic value, indicating a lower survival rate: presence of distant metastases ( p=0.001), lymph node positivity ( p=0.0009), depth of tumor infiltration ( p=0.04), age over 50 ( p=0.02), proximally located tumors ( p=0.03), and ulceroinfiltrative or diffusely infiltrative macroscopic aspect (p=0.0002). The pT2N1-3 staged cases showed a worse prognosis compared with the pT3N0 ones ( p=0.02). Regardless of depth of invasion, the lymph node status remains the strongest indicator of the survival rate in GC. The pTN staging system should be adapted and a Dukes-MAC-like staging system should include the following groups: stage A1- T1N0, stage A2-T1N1-3, stage B1-T2N0, stage B2-T2N1-3, stage C1-T3N0, stage C2-T3N1-3, and stage D-T4N0-3. The grade of discohesivity/budding is not a prognostic factor in GC.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalJournal of Investigative Medicine
Issue number2
Publication statusPublished - Feb 2017


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gurzu, S., Sugimura, H., Orlowska, J., Szederjesi, J., Szentirmay, Z., Bara, T., Fetyko, A., & Jung, I. (2017). Proposal of a Dukes-MAC-like staging system for gastric cancer. Journal of Investigative Medicine, 65(2), 316-322.