Propionic acid produced by Propionibacterium acnes strains contributes to their pathogenicity

Gábor Tax, E. Urbán, Zsuzsanna Palotás, Róbert Puskás, Zoltán Kónya, T. Bíró, L. Kemény, Kornélia Szabó

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Propionibacterium acnes is an important member of the skin microbiome. The bacterium can initiate signalling events and changes in cellular properties in keratinocytes. The aim of this study was to analyse the effect of the bacterium on an immortalized human keratinocyte cell line. The results show that various P. acnes strains affect the cell-growth properties of these cells differentially, inducing cytotoxicity in a strain-specific and dosedependent manner. We propose that bacterially secreted propionic acid may contribute to the cytotoxic effect. This acid has a role in maintaining skin pH and exhibits antimicrobial properties, but may also have deleterious effects when the local concentration rises due to excessive bacterial growth and metabolism. These results, together with available data from the literature, may provide insight into the dual role of P. acnes in healthy skin and during pathogenic conditions, as well as the key molecules involved in these functions.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalActa Dermato-Venereologica
Volume96
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Propionibacterium acnes
Virulence
Keratinocytes
Skin
Bacteria
Microbiota
Growth
Cell Line
Acids
propionic acid

Keywords

  • Acne vulgaris
  • Immortalized keratinocyte cell line (HPV-KER)
  • Propionibacterium acnes
  • Propionic acid
  • Short-chain fatty acid

ASJC Scopus subject areas

  • Dermatology

Cite this

Propionic acid produced by Propionibacterium acnes strains contributes to their pathogenicity. / Tax, Gábor; Urbán, E.; Palotás, Zsuzsanna; Puskás, Róbert; Kónya, Zoltán; Bíró, T.; Kemény, L.; Szabó, Kornélia.

In: Acta Dermato-Venereologica, Vol. 96, No. 1, 01.01.2016, p. 43-49.

Research output: Contribution to journalArticle

Tax, Gábor ; Urbán, E. ; Palotás, Zsuzsanna ; Puskás, Róbert ; Kónya, Zoltán ; Bíró, T. ; Kemény, L. ; Szabó, Kornélia. / Propionic acid produced by Propionibacterium acnes strains contributes to their pathogenicity. In: Acta Dermato-Venereologica. 2016 ; Vol. 96, No. 1. pp. 43-49.
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